PDF(Pubmed)
Abstract：
Critically ill children admitted to the pediatric intensive care unit (PICU) face a substantial risk of morbidity and mortality, regardless of whether they are in developed or developing countries. To aid in treatment planning, various prognostic scoring systems have been developed to predict the likelihood of morbidity and death in these young patients. While the sequential organ failure assessment (SOFA) score has been validated as an independent risk predictor for adult mortality in cases of confirmed or suspected sepsis, it is not suitable for use in children due to its lack of age normalization. Children in critical condition often exhibit significant deviations from the normal physiological balance of their bodies. These deviations from the typical range of physiological variables can be leveraged to estimate the extent of these variations and create scoring systems. In this context, the pediatric SOFA (pSOFA) score was developed by modifying the original SOFA score and incorporating age-adjusted cutoffs for various bodily systems. The objective of this review is to assess the effectiveness of the pSOFA score in predicting sepsis-related mortality in pediatric patients within the PICU setting.
摘要：
入住儿科重症监护病房（PICU）的危重患儿面临相当大的发病和死亡风险，无论他们是在发达国家还是在发展中国家。为了帮助制定治疗计划，已经开发了各种预后评分系统来预测这些年轻患者的发病和死亡可能性.虽然序贯器官衰竭评估（SOFA）评分已被验证为确诊或疑似脓毒症患者成人死亡率的独立风险预测因子，由于缺乏年龄正常化，它不适合儿童使用。处于危急状态的儿童通常表现出与他们身体的正常生理平衡的显著偏差。可以利用与生理变量的典型范围的这些偏差来估计这些变化的程度并创建评分系统。在这种情况下，儿科SOFA(pSOFA)评分是通过修改原始SOFA评分并纳入各种身体系统的年龄调整截止值而制定的.本综述的目的是评估pSOFA评分在预测PICU中儿科患者败血症相关死亡率方面的有效性。
