PDF(Pubmed)
Abstract：
UNASSIGNED: Anorexia nervosa (AN) is a mental and behavioral health condition characterized by an intense fear of weight or fat gain, severe restriction of food intake resulting in low body weight, and distorted self-perception of body shape or weight. While substantial research has focused on general anxiety in AN, less is known about eating-related anxiety and its underlying neural mechanisms. Therefore, we sought to characterize anxiety-to-eat in AN and examine the neurometabolic profile within the dorsal anterior cingulate cortex (dACC), a brain region putatively involved in magnifying the threat response.
UNASSIGNED: Women seeking inpatient treatment for AN and women of healthy weight without a lifetime history of an eating disorder (healthy controls; HC) completed a computer-based behavioral task assessing anxiety-to-eat in response to images of higher (HED) and lower (LED) energy density foods. Participants also underwent magnetic resonance spectroscopy of the dACC in a 3 Tesla scanner.
UNASSIGNED: The AN group reported greater anxiety to eat HED and LED foods relative to the HC group. Both groups reported greater anxiety to eat HED foods relative to LED foods. The neurometabolite myo-inositol (mI) was lower in the dACC in AN relative to HC, and mI levels negatively predicted anxiety to eat HED but not LED foods in the AN group only. mI levels in the dACC were independent of body weight, body mass, and general anxiety.
UNASSIGNED: These findings provide critical new insight into the clinically challenging feature and underlying neural mechanisms of eating-related anxiety and indicate mI levels in the dACC could serve as a novel biomarker of illness severity that is independent of body weight to identify individuals vulnerable to disordered eating or eating pathology as well as a potential therapeutic target.
UNASSIGNED: Women seeking inpatient treatment for AN and women of healthy weight without a lifetime history of an eating disorder (healthy controls; HC) completed a computer-based behavioral task assessing anxiety-to-eat in response to images of higher (HED) and lower (LED) energy density foods. Participants also underwent magnetic resonance spectroscopy of the dACC in a 3 Tesla scanner.
UNASSIGNED: The AN group reported greater anxiety to eat HED and LED foods relative to the HC group. Both groups reported greater anxiety to eat HED foods relative to LED foods. The neurometabolite myo-inositol (mI) was lower in the dACC in AN relative to HC, and mI levels negatively predicted anxiety to eat HED but not LED foods in the AN group only. mI levels in the dACC were independent of body weight, body mass, and general anxiety.
UNASSIGNED: These findings provide critical new insight into the clinically challenging feature and underlying neural mechanisms of eating-related anxiety and indicate mI levels in the dACC could serve as a novel biomarker of illness severity that is independent of body weight to identify individuals vulnerable to disordered eating or eating pathology as well as a potential therapeutic target.
摘要：
■神经性厌食症（AN）是一种精神和行为健康状况，其特征是对体重或脂肪增加的强烈恐惧，严重限制食物摄入导致低体重，和扭曲的身体形状或体重的自我感知。虽然大量研究集中在AN的一般焦虑上，人们对与饮食相关的焦虑及其潜在的神经机制知之甚少。因此,我们试图在AN中描述“进食焦虑”，并检查背侧前扣带皮质（dACC）内的神经代谢谱，假定参与放大威胁反应的大脑区域。
■寻求AN住院治疗的妇女和体重健康而没有饮食失调史的妇女（健康对照；HC）完成了一项基于计算机的行为任务，评估“进食焦虑””以响应较高（HED）和较低（LED）能量密度食物的图像。参与者还在3T扫描仪中进行了dACC的磁共振波谱检查。
■与HC组相比，AN组报告对食用HED和LED食物的焦虑程度更高。两组报告说，相对于LED食品，他们对吃HED食品的焦虑程度更高。相对于HC，AN中dACC中的神经代谢物肌醇（mI）较低，和MI水平负向预测焦虑吃HED而不是LED食物仅在AN组中。dACC中的MI水平与体重无关，体重,和一般的焦虑。
这些发现为饮食相关焦虑的临床挑战性特征和潜在神经机制提供了重要的新见解。并表明dACC中的mI水平可以作为疾病严重程度的新生物标志物，该生物标志物与体重无关，以识别易出现饮食紊乱或饮食病理的个体以及潜在的治疗靶标。
■寻求AN住院治疗的妇女和体重健康而没有饮食失调史的妇女（健康对照；HC）完成了一项基于计算机的行为任务，评估“进食焦虑””以响应较高（HED）和较低（LED）能量密度食物的图像。参与者还在3T扫描仪中进行了dACC的磁共振波谱检查。
■与HC组相比，AN组报告对食用HED和LED食物的焦虑程度更高。两组报告说，相对于LED食品，他们对吃HED食品的焦虑程度更高。相对于HC，AN中dACC中的神经代谢物肌醇（mI）较低，和MI水平负向预测焦虑吃HED而不是LED食物仅在AN组中。dACC中的MI水平与体重无关，体重,和一般的焦虑。
这些发现为饮食相关焦虑的临床挑战性特征和潜在神经机制提供了重要的新见解。并表明dACC中的mI水平可以作为疾病严重程度的新生物标志物，该生物标志物与体重无关，以识别易出现饮食紊乱或饮食病理的个体以及潜在的治疗靶标。
