PDF(Pubmed)
Abstract：
UNASSIGNED: While GBMSM constitute less than 2% of Ghana\'s population, their HIV prevalence surpasses the national average by more than eightfold, emphasizing the critical need for targeted interventions to improve detection, care linkage, and reduce community transmission. This study seeks to increase HIV testing, Pre-Exposure Prophylaxis (PrEP), and Antiretroviral Therapy (ART) uptake (HPART) among YGBMSM through the adaptation of an evidence-based intervention (LAFIYA).
UNASSIGNED: We will employ the ADAPTT-IT framework to adapt LAFIYA and evaluate its feasibility and effectiveness in addressing intersectional stigma and increasing HPART uptake among YGBMSM residing in Ghanaian slums. In aim 1, we will hold focus groups (n=5) and interviews (n=20) among YGBMSM and two FGDs among GBMSM-led organizations. At the HCF level, we will hold 6 FGDs and interviews (n=20) among nurses. In AIM 2, we will randomly assign 6 healthcare facilities (HCFs) to receive the LAFIYA (n=3) or wait-list control (n=3). Friend groups (cluster) of YGBMSM (N=240) will be assigned to receive LAFIYA (n=120) or a wait-list control (n=120). We will collect 3-, 6-, and 9-months post-intervention data among YGBMSM(n=240) and HCWs(n=300) to measure HPART adherence (primary outcomes), ISD reduction, HIV and status-neutral knowledge (secondary outcomes), and intervention acceptability, appropriateness, and feasibility (implementation outcomes).
UNASSIGNED: The intervention group will observe increased HPART adherence, reduced ISD, and enhanced HPART knowledge and efficacy relative to the wait-list control group. The findings will inform ISD reduction and HIV status-neutral implementation strategies - and place-based interventions that address access to HIV prevention and care among YGBMSM, slum and in different settings.
UNASSIGNED: This study was registered on clinicalTrail.gov, with identifier number NCT06312514 on 03/14/2023. https://classic.clinicaltrials.gov/ct2/show/NCT06312514.
UNASSIGNED: We will employ the ADAPTT-IT framework to adapt LAFIYA and evaluate its feasibility and effectiveness in addressing intersectional stigma and increasing HPART uptake among YGBMSM residing in Ghanaian slums. In aim 1, we will hold focus groups (n=5) and interviews (n=20) among YGBMSM and two FGDs among GBMSM-led organizations. At the HCF level, we will hold 6 FGDs and interviews (n=20) among nurses. In AIM 2, we will randomly assign 6 healthcare facilities (HCFs) to receive the LAFIYA (n=3) or wait-list control (n=3). Friend groups (cluster) of YGBMSM (N=240) will be assigned to receive LAFIYA (n=120) or a wait-list control (n=120). We will collect 3-, 6-, and 9-months post-intervention data among YGBMSM(n=240) and HCWs(n=300) to measure HPART adherence (primary outcomes), ISD reduction, HIV and status-neutral knowledge (secondary outcomes), and intervention acceptability, appropriateness, and feasibility (implementation outcomes).
UNASSIGNED: The intervention group will observe increased HPART adherence, reduced ISD, and enhanced HPART knowledge and efficacy relative to the wait-list control group. The findings will inform ISD reduction and HIV status-neutral implementation strategies - and place-based interventions that address access to HIV prevention and care among YGBMSM, slum and in different settings.
UNASSIGNED: This study was registered on clinicalTrail.gov, with identifier number NCT06312514 on 03/14/2023. https://classic.clinicaltrials.gov/ct2/show/NCT06312514.
摘要：
背景虽然GBMSM占加纳人口的不到2%，他们的艾滋病毒感染率超过全国平均水平八倍以上，强调迫切需要有针对性的干预措施来提高检测，护理联动，减少社区传播。这项研究旨在增加艾滋病毒检测，暴露前预防（PrEP），和抗逆转录病毒治疗（ART）吸收（HPART）YGBMSM通过适应循证干预（LAFIYA）。方法我们将采用ADAPTT-IT框架来适应LAFIYA，并评估其在解决加纳贫民窟YGBMSM之间的交叉污名和增加HPART吸收方面的可行性和有效性。在目标1中，我们将在YGBMSM中举行焦点小组（n=5）和访谈（n=20），在GBMSM领导的组织中举行两个FGD。在HCF水平,我们将在护士中举行6次FGD和访谈(n=20)。在AIM2中，我们将随机分配6个医疗机构（HCF）来接收LAFIYA（n=3）或等待列表控制（n=3）。YGBMSM（N=240）的朋友组（集群）将被分配为接收LAFIYA（n=120）或等待列表控件（n=120）。我们将收集3,6-，以及YGBMSM（n=240）和HCWs（n=300）的干预后9个月数据，以测量HPART依从性（主要结果），ISD减少,HIV和状态中性知识（次要结果），和干预的可接受性，适当性，和可行性(实施结果)。结论干预组会观察到HPART依从性的提高,降低ISD,与等待名单对照组相比，HPART知识和疗效得到增强。调查结果将为减少ISD和艾滋病毒地位中立的实施战略以及基于地点的干预措施提供信息，以解决YGBMSM中获得艾滋病毒预防和护理的问题。贫民窟和不同的设置。跟踪注册这项研究在clinicalTrail.gov上注册，标识符号为NCT06312514，日期为2023年3月14日。https://经典。clinicaltrials.gov/ct2/show/NCT06312514.
