PDF(Pubmed)
Abstract：
UNASSIGNED: The association between vitamin A and single cardiometabolic diseases has been extensively studied, but the relationship between dietary vitamin A intake and the risk of cardiometabolic multimorbidity (CMM) has not been studied. Therefore, the present study was conducted to explore the association with CMM risk by analyzing different sources of vitamin A.
UNASSIGNED: This study utilized 13,603 subjects aged ≥ 18 years from 1997-2015 from the China Health and Nutrition Survey (CHNS). Dietary intake was calculated from 3 consecutive 24-h dietary recalls combined with a house hold food inventory. CMM is defined as the development of at least two cardiometabolic diseases.
UNASSIGNED: After a median follow-up of 9.1 years, there were 1050 new cases of CMM. The risk of CMM was significantly lower in those with higher vitamin A intake (Q1 vs Q5 HR 0.66, 95% CI 0.54-0.81). β-carotene (Q1 vs Q5 HR 0.82, 95% CI 0.66-1.02) and retinol (Q1 vs Q5 HR 0.59, 95%CI 0.48-0.73) intake had a similarly negative correlation. Using restricted cubic spline found an L-shaped relationship between retinol intake and CMM (p non-linear < 0.001). In subgroup analyses, protective effects were stronger for participants aged ≥ 44 years (HR 0.72, 95%CI 0.57-0.92) and for the female group (HR 0.62, 95%CI 0.45-0.84).
UNASSIGNED: Dietary vitamin A was a protective factor for CMM, and this effect was stronger in age ≥ 44 years and in the female group. There was a ceiling effect on the protective effect of retinol intake on the risk of CMM.
UNASSIGNED: This study utilized 13,603 subjects aged ≥ 18 years from 1997-2015 from the China Health and Nutrition Survey (CHNS). Dietary intake was calculated from 3 consecutive 24-h dietary recalls combined with a house hold food inventory. CMM is defined as the development of at least two cardiometabolic diseases.
UNASSIGNED: After a median follow-up of 9.1 years, there were 1050 new cases of CMM. The risk of CMM was significantly lower in those with higher vitamin A intake (Q1 vs Q5 HR 0.66, 95% CI 0.54-0.81). β-carotene (Q1 vs Q5 HR 0.82, 95% CI 0.66-1.02) and retinol (Q1 vs Q5 HR 0.59, 95%CI 0.48-0.73) intake had a similarly negative correlation. Using restricted cubic spline found an L-shaped relationship between retinol intake and CMM (p non-linear < 0.001). In subgroup analyses, protective effects were stronger for participants aged ≥ 44 years (HR 0.72, 95%CI 0.57-0.92) and for the female group (HR 0.62, 95%CI 0.45-0.84).
UNASSIGNED: Dietary vitamin A was a protective factor for CMM, and this effect was stronger in age ≥ 44 years and in the female group. There was a ceiling effect on the protective effect of retinol intake on the risk of CMM.
摘要：
背景维生素A与单一心脏代谢疾病之间的关系已被广泛研究，但膳食维生素A摄入量与心脏代谢多发病(CMM)风险之间的关系尚未被研究.因此,本研究通过分析不同来源的维生素A,探讨与CMM风险的相关性。方法本研究利用了1997-2015年中国健康与营养调查(CHNS)中13,603名年龄≥18岁的受试者.饮食摄入量是根据连续3次24小时的饮食召回以及房屋食物库存计算得出的。CMM被定义为至少两种心脏代谢疾病的发展。结果经过9.1年的中位随访，有1050例新的CMM病例。在维生素A摄入量较高的人群中，CMM的风险显着降低（Q1与Q5HR0.66，95％CI0.54-0.81）。β-胡萝卜素（Q1vsQ5HR0.82，95％CI0.66-1.02）和视黄醇（Q1vsQ5HR0.59，95CI0.48-0.73）的摄入量呈类似的负相关。使用有限的三次样条发现视黄醇摄入量与CMM之间存在L形关系（p非线性<0.001）。在亚组分析中，年龄≥44岁(HR0.72,95CI0.57~0.92)和女性组(HR0.62,95CI0.45~0.84)的保护作用更强.结论膳食维生素A是CMM的保护因素,在年龄≥44岁和女性组中，这种影响更强。视黄醇摄入对CMM风险的保护作用存在上限效应。
