Abstract：
Interest in causes of mortality of free-ranging, native North American lagomorphs has grown with the emergence of rabbit hemorrhagic disease virus 2 (RHDV2). Over the years 2013-2022, the Southeastern Cooperative Wildlife Disease Study received 119 Sylvilagus spp. case submissions from the central and eastern United States, comprising 147 rabbits. Most (86%) of these submissions occurred after detecting RHDV2 in the United States in 2020. Laboratory data from these rabbits were retrospectively evaluated for major causes, contributors to mortality, and pathogen detections. Gross and histologic examination was performed for 112 rabbits. Common primary causes of death included trauma (n = 49), bacterial disease (n = 31), emaciation (n = 6), and parasitism (n = 6). Among the 32 rabbits with bacterial disease, 12 were diagnosed with tularemia and 7 with pasteurellosis. Rabbits with pasteurellosis had disseminated abscessation, septicemia, and/or polyserositis. Less commonly, cutaneous fibroma (n = 2), notoedric mange (n = 2), encephalitozoonosis (n = 2), neoplasia (round-cell sarcoma; n = 1), and congenital abnormalities (n = 1) were diagnosed. RHDV2 was not detected in 123 rabbits tested. Although RHDV2 has not been detected in wild lagomorphs in the eastern United States, detections in domestic rabbits from the region emphasize the need for continued surveillance. Furthermore, continued surveillance for Francisella tularensis informs public health risk. Overall, increased knowledge of Sylvilagus spp. health furthers our understanding of diseases affecting these important prey and game species.
摘要：
对自由放养死亡原因的兴趣，随着兔出血性疾病病毒2（RHDV2）的出现，北美本土的lagomorphs也随之生长。在2013-2022年期间，东南合作野生动物疾病研究收到了119个Sylvilagusspp。美国中部和东部提交的案件，147只兔子这些提交的大多数（86％）是在2020年在美国检测到RHDV2之后发生的。对这些兔子的实验室数据进行了回顾性评估，以了解主要原因。死亡率的贡献者，和病原体检测。对112只兔子进行了大体和组织学检查。常见的主要死亡原因包括创伤（n=49），细菌性疾病（n=31），消瘦(n=6)，和寄生(n=6)。在32只患有细菌性疾病的兔子中，12例被诊断为tularemia，7例被诊断为巴氏病。患有巴氏杆菌病的兔子已传播脓肿，败血症,和/或多发性浆膜炎。不太常见，皮肤纤维瘤（n=2），notoedricmange(n=2)，类脑人畜共患病（n=2），瘤形成（圆细胞肉瘤；n=1），和先天性异常（n=1）被诊断。在测试的123只兔子中未检测到RHDV2。尽管在美国东部的野生lagomorphs中尚未检测到RHDV2，对该地区家兔的检测强调了继续监测的必要性。此外，继续监测土伦弗朗西斯菌可告知公共卫生风险。总的来说,增加了对Sylvilagusspp的了解。健康促进了我们对影响这些重要猎物和游戏物种的疾病的理解。
