PDF(Pubmed)
Abstract：
Injectable fillers, pivotal in aesthetic medicine, have evolved significantly with recent trends favoring biostimulators like calcium hydroxylapatite (CaHA-CMC; Radiesse, Merz Aesthetics, Raleigh, NC) and poly-l-lactic acid (PLLA; Sculptra Aesthetics, Galderma, Dallas, TX). This study aims to compare the particle morphology of these two injectables and examine its potential clinical implications. Utilizing advanced light and scanning electron microscopy techniques, the physical characteristics of CaHA-CMC and PLLA particles were analyzed, including shape, size, circularity, roundness, aspect ratio, and quantity of phagocytosable particles. The findings reveal several morphological contrasts: CaHA-CMC particles exhibited a smooth, homogenous, spherical morphology with diameters predominantly ranging between 20 and 45 µm, while PLLA particles varied considerably in shape and size, appearing as micro flakes ranging from 2 to 150 µm in major axis length. The circularity and roundness of CaHA-CMC particles were significantly higher compared to PLLA, indicating a more uniform shape. Aspect ratio analysis further underscored these differences, with CaHA-CMC particles showing a closer resemblance to circles, unlike the more oblong PLLA particles. Quantification of the phagocytosable content of both injectables revealed a higher percentage of phagocytosable particles in PLLA. These morphological distinctions may influence the tissue response to each treatment. CaHA-CMC\'s uniform, spherical particles may result in reduced inflammatory cell recruitment, whereas PLLA\'s heterogeneous particle morphology may evoke a more pronounced inflammatory response.
摘要：
可注射填充剂,在美学医学中至关重要，随着最近的趋势，如羟基磷灰石钙(CaHA-CMC;辐射，Merz美学,罗利,NC)和聚-1-乳酸(PLLA；雕塑美学，Galderma,达拉斯,TX）。本研究旨在比较这两种注射剂的颗粒形态，并研究其潜在的临床意义。利用先进的光和扫描电子显微镜技术，分析了CaHA-CMC和PLLA颗粒的物理特性,包括形状,尺寸,循环性,圆度,纵横比,和可吞噬颗粒的数量。研究结果揭示了几种形态对比：CaHA-CMC颗粒表现出光滑，同质，直径主要在20到45微米之间的球形形态，虽然PLLA颗粒的形状和大小差异很大，出现在主轴长度范围从2到150µm的微米薄片。CaHA-CMC颗粒的圆度和圆度明显高于PLLA,表示更均匀的形状。纵横比分析进一步强调了这些差异，CaHA-CMC颗粒显示出更接近圆形的相似性，不同于更长方形的PLLA颗粒。两种注射剂的可吞噬含量的定量显示PLLA中可吞噬颗粒的百分比更高。这些形态学差异可能影响组织对每种治疗的反应。CaHA-CMC的制服,球形颗粒可能导致炎症细胞募集减少，而PLLA的异质颗粒形态可能引起更明显的炎症反应。
