Abstract：
OBJECTIVE: Subsequent vertebral fracture (SVF) is a severe advent event of percutaneous vertebral augmentation (PVA). However, the incidence and risk factors of SVF following PVA for OVCF in postmenopausal women remain unclear. This research aims to investigative the incidence and risk factors of SVF after PVA for OVCF in postmenopausal women.
METHODS: Women who underwent initial PVA for OVCF between August 2019 and December 2021 were reviewed. Univariate logistic regression analysis was performed to identify possible risk factors of SVF, and independent risk factors were determined by multivariate logistic regression.
RESULTS: A total of 682 women after menopause were enrolled in the study. Of these women, 100 cases had an SVF after PVA, with the incidence of 14.66%. Univariate logistic regression analysis demonstrated that age (p = 0.001), body mass index (BMI) (p < 0.001), steroid use (p = 0.008), history of previous vertebral fracture (p < 0.001), multiple vertebral fracture (p = 0.033), postoperative wedge angle (p = 0.003), and HU value (p < 0.001) were significantly correlated with SVF following PVA. Furthermore, BMI (OR [95%CI] = 0.892 [0.825 - 0.965]; p = 0.004), steroid use (OR [95%CI] = 3.029 [1.211 - 7.574]; p = 0.018), history of previous vertebral fracture (OR [95%CI] = 1.898 [1.148 - 3.139]; p = 0.013), postoperative wedge angle (OR [95%CI] = 1.036 [1.004 - 1.070]; p = 0.028), and HU value (OR [95%CI] = 0.980 [0.971 - 0.990]; p < 0.001) were identified as independent risk factors of SVF after PVA by multivariate logistic regression analysis.
CONCLUSIONS: The incidence of SVF following PVA for OVCF in postmenopausal women was 14.66%. BMI, steroid use, history of previous vertebral fracture, postoperative wedge angle, and HU value were independent risk factors of SVF after PVA for OVCF in postmenopausal women.
METHODS: Women who underwent initial PVA for OVCF between August 2019 and December 2021 were reviewed. Univariate logistic regression analysis was performed to identify possible risk factors of SVF, and independent risk factors were determined by multivariate logistic regression.
RESULTS: A total of 682 women after menopause were enrolled in the study. Of these women, 100 cases had an SVF after PVA, with the incidence of 14.66%. Univariate logistic regression analysis demonstrated that age (p = 0.001), body mass index (BMI) (p < 0.001), steroid use (p = 0.008), history of previous vertebral fracture (p < 0.001), multiple vertebral fracture (p = 0.033), postoperative wedge angle (p = 0.003), and HU value (p < 0.001) were significantly correlated with SVF following PVA. Furthermore, BMI (OR [95%CI] = 0.892 [0.825 - 0.965]; p = 0.004), steroid use (OR [95%CI] = 3.029 [1.211 - 7.574]; p = 0.018), history of previous vertebral fracture (OR [95%CI] = 1.898 [1.148 - 3.139]; p = 0.013), postoperative wedge angle (OR [95%CI] = 1.036 [1.004 - 1.070]; p = 0.028), and HU value (OR [95%CI] = 0.980 [0.971 - 0.990]; p < 0.001) were identified as independent risk factors of SVF after PVA by multivariate logistic regression analysis.
CONCLUSIONS: The incidence of SVF following PVA for OVCF in postmenopausal women was 14.66%. BMI, steroid use, history of previous vertebral fracture, postoperative wedge angle, and HU value were independent risk factors of SVF after PVA for OVCF in postmenopausal women.
摘要：
目的：后续椎体骨折（SVF）是经皮椎体强化（PVA）的严重事件。然而,在绝经后女性中,PVA治疗OVCF后SVF的发生率和危险因素尚不清楚.本研究旨在探讨绝经后妇女PVA治疗OVCF后SVF的发生率和危险因素。
方法：对在2019年8月至2021年12月期间接受初次PVA治疗OVCF的女性进行了回顾。进行单因素logistic回归分析以确定SVF的可能危险因素。并通过多因素logistic回归确定独立危险因素。
结果：共有682名绝经后妇女参加了这项研究。在这些女人中,100例PVA术后有SVF，发病率为14.66%。单因素Logistic回归分析表明，年龄(p=0.001)，体重指数（BMI）（p<0.001），类固醇使用（p=0.008），既往椎体骨折史（p<0.001），多发性椎体骨折（p=0.033），术后楔角（p=0.003），和HU值(p<0.001)与PVA后的SVF显著相关。此外，BMI（OR[95CI]=0.892[0.825-0.965]；p=0.004），类固醇使用（OR[95CI]=3.029[1.211-7.574]；p=0.018），既往椎体骨折病史（OR[95CI]=1.898[1.148-3.139]；p=0.013），术后楔角（OR[95CI]=1.036[1.004-1.070]；p=0.028），和HU值（OR[95CI]=0.980[0.971-0.990];p<0.001）被确定为PVA后SVF的独立危险因素。
结论：在绝经后妇女中，PVA后的SVF发生率为14.66％。BMI,使用类固醇,既往椎骨骨折史，术后楔角,和HU值是绝经后妇女PVA术后SVF发生OVCF的独立危险因素。
方法：对在2019年8月至2021年12月期间接受初次PVA治疗OVCF的女性进行了回顾。进行单因素logistic回归分析以确定SVF的可能危险因素。并通过多因素logistic回归确定独立危险因素。
结果：共有682名绝经后妇女参加了这项研究。在这些女人中,100例PVA术后有SVF，发病率为14.66%。单因素Logistic回归分析表明，年龄(p=0.001)，体重指数（BMI）（p<0.001），类固醇使用（p=0.008），既往椎体骨折史（p<0.001），多发性椎体骨折（p=0.033），术后楔角（p=0.003），和HU值(p<0.001)与PVA后的SVF显著相关。此外，BMI（OR[95CI]=0.892[0.825-0.965]；p=0.004），类固醇使用（OR[95CI]=3.029[1.211-7.574]；p=0.018），既往椎体骨折病史（OR[95CI]=1.898[1.148-3.139]；p=0.013），术后楔角（OR[95CI]=1.036[1.004-1.070]；p=0.028），和HU值（OR[95CI]=0.980[0.971-0.990];p<0.001）被确定为PVA后SVF的独立危险因素。
结论：在绝经后妇女中，PVA后的SVF发生率为14.66％。BMI,使用类固醇,既往椎骨骨折史，术后楔角,和HU值是绝经后妇女PVA术后SVF发生OVCF的独立危险因素。
