Abstract：
Errors in human DNA may cause genetic disorders. Technological developments have raised hopes for reducing the risks of genetic inheritance among married couples who have a history of such disorders. Among the developments in reproductive health technology that reduce those risks is the in vitro fertilization (IVF) process. This review aimed to describe the current strategies using IVF and preimplantation genetic testing (PGT), which would be effective for couples with genetic disorders to have healthy offspring. The literature review included full-text, open-access research articles from ScienceDirect, PubMed, and Google Scholar that were published between 2013 and 2023, with 65 articles obtained from various journals. The keywords were \"in vitro fertilization,\" \"reproductive genetic disorders,\" \"PGT-A,\" \"PGT-M,\" \"PGT-SR,\" and \"oocyte donor.\" A total of 46 articles were selected as the most relevant to the review topic, and the results show that the IVF process can be an option for couples with a history of genetic disorders. Several additional procedures can be performed following IVF, such as oocyte donation and PGT, to help couples who want to have offspring without transmitting their genetic disorders. IVF can be an option for couples who have or carry genetic disorders. With IVF, couples can undertake several procedures such as oocyte donation and PGT for aneuploidy, monogenic disorders, or structural rearrangement.
摘要：
人类DNA的错误可能会导致遗传疾病。技术的发展为降低有此类疾病史的已婚夫妇的遗传风险带来了希望。减少这些风险的生殖健康技术的发展包括体外受精（IVF）过程。这篇综述旨在描述目前使用IVF和植入前基因检测（PGT）的策略，这对患有遗传疾病的夫妇有健康的后代是有效的。文献综述包括全文，来自ScienceDirect的开放获取研究文章，PubMed,和谷歌学者在2013年至2023年之间发表，从各种期刊上获得了65篇文章。关键词是“体外受精”，“”生殖遗传疾病，\"\"PGT-A,\"\"PGT-M,\"\"PGT-SR,“和”卵母细胞供体。"共选取46篇作为与复习题目最相关的文章,结果表明，IVF过程可以成为有遗传疾病史的夫妇的选择。IVF后可以执行几个额外的程序，例如卵母细胞捐赠和PGT，帮助那些想要后代而不传播遗传疾病的夫妇。IVF可以是患有或携带遗传疾病的夫妇的选择。有了IVF,夫妇可以进行几种程序，如卵母细胞捐赠和PGT进行非整倍体，单基因疾病，或结构重组。
