Abstract：
Pyoderma gangrenosum (PG) is a sterile inflammatory skin condition that is frequently associated with immune-related diseases, including inflammatory bowel disease (IBD). PG causes noninfectious ulcers. Facial PG is uncommon while PG usually occurs on the trunk and lower limbs. Herein, we report a case of a male teenager with fever, pustules, ulcers, and necrosis on both cheeks. He was initially diagnosed with complicated acne with bacterial infection, but the condition progressed to subcutaneous ulcers despite treatment. Biopsy revealed inflammatory lesions in dermal and subcutaneous tissue with neutrophil infiltration, consistent with PG. Although lacking typical IBD symptoms, blood tests revealed anemia and positive fecal occult blood. Sigmoidoscopy revealed inflammation, ulcers, and pseudopolyps in the colon and rectum, thereby diagnosing ulcerative colitis (UC). After treating PG and UC with prednisolone and skin grafts, golimumab was prescribed. The patient is now in remission. Necrotic tissue buildup can complicate closure in PG cases;this emphasizes the need for effective IBD treatment to facilitate procedures such as skin grafts.
摘要：
坏疽性脓皮病（PG）是一种无菌炎性皮肤病，通常与免疫相关疾病有关，包括炎症性肠病（IBD）。PG引起非感染性溃疡。面部PG并不常见，而PG通常发生在躯干和下肢。在这里，我们报道了一个男性青少年发烧的病例，脓疱,溃疡,两颊坏死.他最初被诊断出患有细菌感染的复杂痤疮，但尽管经过治疗，病情还是进展为皮下溃疡。活检显示皮肤和皮下组织有炎症病变伴中性粒细胞浸润，与PG一致。虽然缺乏典型的IBD症状，血液检查显示贫血和粪便隐血阳性。乙状结肠镜检查显示有炎症,溃疡,结肠和直肠的假息肉，从而诊断溃疡性结肠炎(UC)。用泼尼松龙和皮肤移植治疗PG和UC后，戈利木单抗是处方.患者现在处于缓解状态。在PG病例中，坏死组织的积聚会使闭合复杂化；这强调了需要有效的IBD治疗以促进诸如皮肤移植之类的程序。
