Abstract：
Surgical site infection (SSI) is a common complication after celiotomy in horses, leading to increased morbidity and costs. Increased concern about antibiotic resistance justifies evaluation of alternative preventive approaches, such a Manuka honey which has displayed antimicrobial properties. Pectin-Honey Hydrogels (PHH), composed by Manuka honey and pectin provide a moist wound environment and microbial growth inhibition. The aim of the study was to evaluate the effectiveness of PHHs in preventing SSI in horses subjected to emergency laparotomy. Horses undergoing laparotomy were evaluated. Horses were randomly divided into two groups: Group 1 received PHH application onto the sutured linea alba before skin closure, while Group 2 received no treatment. Horses with postoperative antimicrobial administration or survival of less than 5 days were excluded. The incidence of SSIs was reported as percentages and compared between groups. Out of 44 horses enrolled in the study, only thirty-six were ultimately included. Exclusions occurred either due to death before 5 days postoperatively (2 horses) or the administration of postoperative antimicrobials (6 horses). The median length of hospitalization was 9 days (range 8-14 days). The overall occurrence of SSI was 19.4 %. One out of eighteen horses (5.5 %) in Group 1 and 6 out of 18 (33.3 %) horses in Group 2 developed SSI. Group 2 had an 8.5-fold increased risk of SSI (p = 0.035, OR = 8.5, 95 % CI. 0.9-80.07). No macroscopically visible adverse reactions were associated with PHH. PHH placed at the abdominal incision during surgery was safe and reduced the prevalence of SSI in horses.
摘要：
手术部位感染（SSI）是马开腹手术后的常见并发症，导致发病率和成本增加。对抗生素耐药性的日益关注证明了对替代预防方法的评估是合理的，这种麦卢卡蜂蜜具有抗菌特性。果胶蜂蜜水凝胶（PHH），由麦卢卡蜂蜜和果胶提供潮湿的伤口环境和微生物生长抑制。该研究的目的是评估PHHs预防急诊剖腹手术马匹SSI的有效性。对进行剖腹手术的马进行了评估。马被随机分为两组：第1组在皮肤闭合前接受PHH应用到缝合的白线上，而第2组未接受治疗。排除术后施用抗菌药物或存活少于5天的马。SSIs的发生率报告为百分比，并在组间进行比较。在参加这项研究的44匹马中，最终只包括36个。排除是由于术后5天之前死亡（2匹马）或术后服用抗微生物剂（6匹马）。平均住院时间为9天（范围8-14天）。SSI的总发生率为19.4%。第1组的18匹马中的1匹（5.5％）和第2组的18匹马中的6匹（33.3％）发展为SSI。第2组发生SSI的风险增加8.5倍（p=0.035，OR=8.5，95%CI。0.9-80.07）。没有肉眼可见的不良反应与PHH相关。手术期间放置在腹部切口处的PHH是安全的，并降低了马的SSI患病率。
