肉笋多糖功能化树枝状纤维纳米二氧化硅为基础的佐剂用于 H9N2 口服疫苗增强鸡的全身和黏膜免疫。
关键词: 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC·HOL) 3-aminopropyltriethoxysilane (APTES) Adjuvant Cistanche deserticola polysaccharide (CDP) Dendritic fibrous nano-silica H(9)N(2) Lipopolysaccharide (LPS) Mucosal and systemic immunity N-Hydroxy succinimide (NHS) Oral vaccine cetyltrimethylammonium bromide (CTAB) phytohaemagglutinin (PHA) sodium salicylate (Nasal) tetraethoxysilane (TEOS) triethanolamine (TEA)
Mesh : Animals Influenza A Virus, H9N2 Subtype / immunology drug effects Chickens Polysaccharides / administration & dosage pharmacology chemistry immunology Silicon Dioxide / administration & dosage chemistry Nanoparticles / administration & dosage Influenza Vaccines / administration & dosage immunology Immunity, Mucosal / drug effects Influenza in Birds / prevention & control immunology Adjuvants, Immunologic / administration & dosage pharmacology Administration, Oral Intestinal Mucosa / immunology drug effects Antibodies, Viral / blood immunology
来 源: DOI:10.1016/j.ijpharm.2024.124318