Abstract：
The Brazilian Amazon is home to a rich fauna of scorpion species of medical importance, some of them still poorly characterized regarding their biological actions and range of clinical symptoms after envenoming. The Amazonian scorpion species Tityus strandi and Tityus dinizi constitute some of the scorpions in this group, with few studies in the literature regarding their systemic repercussions. In the present study, we characterized the clinical, inflammatory, and histopathological manifestations of T. strandi and T. dinizi envenoming in a murine model using Balb/c mice. The results show a robust clinical response based on clinical score, hyperglycemia, leukocytosis, increased cytokines, and histopathological changes in the kidneys and lungs. Tityus strandi envenomed mice presented more prominent clinical manifestations when compared to Tityus dinizi, pointing to the relevance of this species in the medical scenario, with both species inducing hyperglycemia, leukocytosis, increased cytokine production in the peritoneal lavage, increased inflammatory infiltrate in the lungs, and acute tubular necrosis after T. strandi envenoming. The results presented in this research can help to understand the systemic manifestations of scorpion accidents in humans caused by the target species of the study and point out therapeutic strategies in cases of scorpionism in remote regions of the Amazon.
摘要：
巴西亚马逊是丰富的蝎子动物的家园，具有医学意义，在envenoming后，其中一些在生物学作用和临床症状范围方面的特征仍然很差。亚马逊蝎种Tityusstrandi和Tityusdinizi构成了该组中的一些蝎子，文献中关于其系统性影响的研究很少。在本研究中,我们描述了临床特征，炎症，以及在使用Balb/c小鼠的小鼠模型中T.strandi和T.dinizienvening的组织病理学表现。结果显示基于临床评分的稳健临床反应，高血糖症,白细胞增多,增加的细胞因子，肾脏和肺的组织病理学改变.与Tityusdinizi相比，Tityusstrandienvenomed小鼠表现出更突出的临床表现，指出这个物种在医学场景中的相关性，这两个物种都会诱发高血糖，白细胞增多,腹腔灌洗中细胞因子的产生增加，肺部炎症浸润增加，和T.strandienvening后的急性肾小管坏死。这项研究中提出的结果可以帮助了解由研究的目标物种引起的人类蝎子事故的系统性表现，并指出亚马逊偏远地区蝎子行为的治疗策略。
