Abstract：
Dengue is a mosquito-transmitted infection endemic in tropical and subtropical locations of the world where nearly half of the world\'s population resides. The disease may present as mild febrile illness to severe and can even be fatal if untreated. There are four genetically related but antigenically distinct dengue virus (DENV) serotypes. Immune responses to DENV infection are in general protective but under certain conditions, they can also aggravate the disease. The importance of the cellular immune responses and the antibody responses involving IgG and IgM has been well-studied. In contrast, not much has been described on the potential role of hypersensitivity reactions involving IgE in dengue. Several studies have shown elevated levels of IgE in patients with dengue fever, but its involvement in the immune response against the virus and disease is unknown. Activation of mast cells (MCs) and basophils mediated through dengue-specific IgE could result in the release of mediators affecting dengue virus infection. The present review explores the relationships between the induction of IgE in dengue virus infection, and the potential role of MCs and basophils, exploring both protective and pathogenic aspects, including antibody-dependent enhancement (ADE) of infection in dengue.
摘要：
登革热是世界热带和亚热带地区的一种蚊子传播的传染病，世界上近一半的人口居住在那里。该疾病可能表现为轻度高热至严重的疾病，如果不治疗，甚至可能致命。有四种遗传相关但抗原性不同的登革热病毒(DENV)血清型。对DENV感染的免疫反应通常是保护性的，但在某些条件下，它们也会加重疾病。已经充分研究了细胞免疫应答和涉及IgG和IgM的抗体应答的重要性。相比之下,关于涉及IgE的超敏反应在登革热中的潜在作用，没有太多描述。几项研究表明，登革热患者的IgE水平升高，但它是否参与针对病毒和疾病的免疫反应是未知的。通过登革热特异性IgE介导的肥大细胞（MC）和嗜碱性粒细胞的激活可能导致影响登革病毒感染的介质的释放。本综述探讨IgE在登革病毒感染中的诱导关系,以及MC和嗜碱性粒细胞的潜在作用，探索保护和致病方面，包括登革热感染的抗体依赖性增强（ADE）。
