Abstract：
Total saponins from Panax japonicus (TSPJ) have many beneficial physiological activities, particularly in alleviating the damages of aging and abnormal lipid metabolism. This work used mice models to investigate if TSPJ reduced obesity and regulated metabolic functions via the intestinal microbiota, the disturbance of which has been shown to cause aging-related diseases. The results showed that TSPJ significantly reduced the weight and blood lipid level of aging mice. Further analyses showed that TSPJ significantly inhibited adipogenesis, changed the composition of the intestinal flora, and protected the integrity of the intestinal barrier. It was inferred from the accumulated experimental data that TSPJ helped to combat obesity in aging mice by regulating the intestinal microbiota and promoting microbial metabolism.
摘要：
竹节参总皂苷(TSPJ)具有许多有益的生理活性,特别是在减轻衰老和异常脂质代谢的损害。这项工作使用小鼠模型来研究TSPJ是否通过肠道微生物群减少肥胖和调节代谢功能，其干扰已被证明会导致与衰老有关的疾病。结果表明，TSPJ能显著降低衰老小鼠的体重和血脂水平。进一步的分析表明，TSPJ显著抑制脂肪生成，改变了肠道菌群的组成,并保护肠道屏障的完整性。从积累的实验数据推断，TSPJ通过调节肠道微生物群和促进微生物代谢来帮助对抗衰老小鼠的肥胖。
