Abstract：
UNASSIGNED: To summarise the findings on the effect of the clinical use of 0.1% polyhexanide-propylbetaine (PHMB/betaine) solution/gel on acute and hard-to-heal (chronic) wound healing.
UNASSIGNED: A literature search was conducted in MEDLINE, CINAHL, Embase, Scopus and the CENTRAL Trials Registry of the Cochrane Collaboration. Paired reviewers conducted title and abstract screening and full-text screening to identify experimental, quasi-experimental and observational studies. Study quality and risk of bias were not formally evaluated.
UNASSIGNED: A total of 17 studies met the eligibility criteria. The findings from 12 studies indicated that the use of 0.1% PHMB/betaine solution/gel had: a low risk of contact sensitivity; could help debridement during wound cleansing; aided effective wound bed preparation; reduced wound size, odour and exudate; improved pain control; reduced microbial load; and enhanced wound healing. The results of three studies indicated that both 0.1% PHMB and saline solution were effective in reducing bacterial load, while another showed that adding 0.1% PHMB to tie-over dressings had no effect on reducing bacterial loads in wounds. Another study concluded that disinfection and granulation of pressure ulcers with hydrobalance dressing with 0.3% PHMB was faster and more effective than using 0.1% PHMB/betaine.
UNASSIGNED: The findings of this literature review showed that 0.1% PHMB/betaine solution/gel appeared to be useful and safe for wound cleansing, was effective in removing soft debris and slough from the wound bed, and created a wound environment optimal for healing. Although these actions cannot be attributed solely to this treatment modality, these results do highlight the unique action of this combined product. However, more robust studies are needed to confirm these results.
UNASSIGNED: A literature search was conducted in MEDLINE, CINAHL, Embase, Scopus and the CENTRAL Trials Registry of the Cochrane Collaboration. Paired reviewers conducted title and abstract screening and full-text screening to identify experimental, quasi-experimental and observational studies. Study quality and risk of bias were not formally evaluated.
UNASSIGNED: A total of 17 studies met the eligibility criteria. The findings from 12 studies indicated that the use of 0.1% PHMB/betaine solution/gel had: a low risk of contact sensitivity; could help debridement during wound cleansing; aided effective wound bed preparation; reduced wound size, odour and exudate; improved pain control; reduced microbial load; and enhanced wound healing. The results of three studies indicated that both 0.1% PHMB and saline solution were effective in reducing bacterial load, while another showed that adding 0.1% PHMB to tie-over dressings had no effect on reducing bacterial loads in wounds. Another study concluded that disinfection and granulation of pressure ulcers with hydrobalance dressing with 0.3% PHMB was faster and more effective than using 0.1% PHMB/betaine.
UNASSIGNED: The findings of this literature review showed that 0.1% PHMB/betaine solution/gel appeared to be useful and safe for wound cleansing, was effective in removing soft debris and slough from the wound bed, and created a wound environment optimal for healing. Although these actions cannot be attributed solely to this treatment modality, these results do highlight the unique action of this combined product. However, more robust studies are needed to confirm these results.
摘要：
总结临床使用0.1%聚己胺丙基甜菜碱(PHMB/甜菜碱)溶液/凝胶对急性和难以愈合(慢性)伤口愈合的影响的发现。
■在MEDLINE进行了文献检索，CINAHL,Embase,Scopus和Cochrane协作中心试验登记处。配对审稿人进行标题和摘要筛选和全文筛选，以确定实验，准实验和观察研究。没有对研究质量和偏倚风险进行正式评估。
■共有17项研究符合资格标准。来自12项研究的结果表明，使用0.1％PHMB/甜菜碱溶液/凝胶具有：接触敏感性风险低；可以在伤口清洁期间帮助清创；有助于有效的伤口床准备；减少伤口大小，气味和渗出物；改善疼痛控制；减少微生物负荷；并增强伤口愈合。三项研究的结果表明，0.1%PHMB和盐溶液均能有效减少细菌负荷，而另一项研究表明，在复合敷料中添加0.1%PHMB对降低伤口细菌负荷没有影响。另一项研究得出结论，与使用0.1％PHMB/甜菜碱相比，使用0.3％PHMB的水平衡敷料对压力性溃疡进行消毒和制粒更快，更有效。
■这篇文献综述的发现表明，0.1%PHMB/甜菜碱溶液/凝胶对于伤口清洁似乎是有用和安全的，能有效清除伤口床上的软碎片和腐肉，创造了一个最适合愈合的伤口环境。虽然这些行为不能完全归因于这种治疗方式，这些结果确实突出了这种组合产品的独特作用。然而,需要更有力的研究来证实这些结果.
■在MEDLINE进行了文献检索，CINAHL,Embase,Scopus和Cochrane协作中心试验登记处。配对审稿人进行标题和摘要筛选和全文筛选，以确定实验，准实验和观察研究。没有对研究质量和偏倚风险进行正式评估。
■共有17项研究符合资格标准。来自12项研究的结果表明，使用0.1％PHMB/甜菜碱溶液/凝胶具有：接触敏感性风险低；可以在伤口清洁期间帮助清创；有助于有效的伤口床准备；减少伤口大小，气味和渗出物；改善疼痛控制；减少微生物负荷；并增强伤口愈合。三项研究的结果表明，0.1%PHMB和盐溶液均能有效减少细菌负荷，而另一项研究表明，在复合敷料中添加0.1%PHMB对降低伤口细菌负荷没有影响。另一项研究得出结论，与使用0.1％PHMB/甜菜碱相比，使用0.3％PHMB的水平衡敷料对压力性溃疡进行消毒和制粒更快，更有效。
■这篇文献综述的发现表明，0.1%PHMB/甜菜碱溶液/凝胶对于伤口清洁似乎是有用和安全的，能有效清除伤口床上的软碎片和腐肉，创造了一个最适合愈合的伤口环境。虽然这些行为不能完全归因于这种治疗方式，这些结果确实突出了这种组合产品的独特作用。然而,需要更有力的研究来证实这些结果.
