Abstract：
BACKGROUND: Obesity is a chronic disease that increases the risk of cardiovascular diseases (CVD), including systemic arterial hypertension (SAH), underestimated in this population. The high mortality related to CVD reveals the need for early screening. One of the training tools is the waist-to-hip ratio (WHR). However, few studies evaluate its relationship with metabolic changes in severe obesity, making necessary a new cut-off point.
METHODS: Cross-sectional study with 75 Brazilian women with severe obesity (mean age: 37,6 years; weight of 122 kg and body mass index (BMI) of 47,8 kg/m2). Height, weight, neck circumference (NC), hip (HC), waist (WC) and waist-to-hip ratio (WHR) were obtained. Blood samples were collected for lipid/glucose profile. The Receiver Operating Characteristic (ROC) was explored to define cut-off points for WHR based on SAH. Women were compared using the t-Student/Mann Whitney test. Pearson/Spearman correlations were performed, and the significance level was set at 5%.
RESULTS: The ROC curve indicated that WHR ≥0.92 best predicted SAH. The group with WHR ≥0.92 had higher Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) (p = 0.037), insulin (p = 0.037), NC (p = 0.004), and Atherogenic Index of Plasma (AIP) (p = 0.038). WHR correlated with NC (p = 0.002; r = 0.358), glucose (p = 0.026; r = 0.270); insulin (p = 0.05; r = 0.238); HOMA-IR (p = 0.01; r = 0.3238), triglycerides (p = 0.006; r = 329) and AIP (p = 0.02; r = 0.370).
CONCLUSIONS: A new cut-off point for WHR related to SAH in severe obesity is suggested.
METHODS: Cross-sectional study with 75 Brazilian women with severe obesity (mean age: 37,6 years; weight of 122 kg and body mass index (BMI) of 47,8 kg/m2). Height, weight, neck circumference (NC), hip (HC), waist (WC) and waist-to-hip ratio (WHR) were obtained. Blood samples were collected for lipid/glucose profile. The Receiver Operating Characteristic (ROC) was explored to define cut-off points for WHR based on SAH. Women were compared using the t-Student/Mann Whitney test. Pearson/Spearman correlations were performed, and the significance level was set at 5%.
RESULTS: The ROC curve indicated that WHR ≥0.92 best predicted SAH. The group with WHR ≥0.92 had higher Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) (p = 0.037), insulin (p = 0.037), NC (p = 0.004), and Atherogenic Index of Plasma (AIP) (p = 0.038). WHR correlated with NC (p = 0.002; r = 0.358), glucose (p = 0.026; r = 0.270); insulin (p = 0.05; r = 0.238); HOMA-IR (p = 0.01; r = 0.3238), triglycerides (p = 0.006; r = 329) and AIP (p = 0.02; r = 0.370).
CONCLUSIONS: A new cut-off point for WHR related to SAH in severe obesity is suggested.
摘要：
背景：肥胖是一种慢性疾病，会增加心血管疾病（CVD）的风险，包括系统性动脉高血压（SAH），在这个人口中被低估了。与CVD相关的高死亡率表明需要早期筛查。训练工具之一是腰臀比(WHR)。然而,很少有研究评估其与严重肥胖代谢变化的关系，需要一个新的截止点。
方法：对75名巴西重度肥胖妇女进行横断面研究（平均年龄：37,6岁；体重为122kg，体重指数（BMI）为47,8kg/m2）。高度,体重,颈围（NC），髋部(HC),获得腰围（WC）和腰臀比（WHR）。收集血液样品用于脂质/葡萄糖概况。探索接收器工作特性(ROC)以基于SAH定义WHR的截止点。使用t-Student/MannWhitney测试比较女性。进行了Pearson/Spearman相关性，显著性水平设定为5%。
结果：ROC曲线表明WHR≥0.92最佳预测SAH。WHR≥0.92组的胰岛素抵抗稳态模型评估（HOMA-IR）较高（p=0.037），胰岛素（p=0.037），NC(p=0.004),和血浆致动脉粥样硬化指数(AIP)(p=0.038)。WHR与NC相关(p=0.002；r=0.358)，葡萄糖(p=0.026;r=0.270);胰岛素(p=0.05;r=0.238);HOMA-IR(p=0.01;r=0.3238),甘油三酯(p=0.006;r=329)和AIP(p=0.02;r=0.370)。
结论：建议在重度肥胖中与SAH相关的WHR的新截止点。
方法：对75名巴西重度肥胖妇女进行横断面研究（平均年龄：37,6岁；体重为122kg，体重指数（BMI）为47,8kg/m2）。高度,体重,颈围（NC），髋部(HC),获得腰围（WC）和腰臀比（WHR）。收集血液样品用于脂质/葡萄糖概况。探索接收器工作特性(ROC)以基于SAH定义WHR的截止点。使用t-Student/MannWhitney测试比较女性。进行了Pearson/Spearman相关性，显著性水平设定为5%。
结果：ROC曲线表明WHR≥0.92最佳预测SAH。WHR≥0.92组的胰岛素抵抗稳态模型评估（HOMA-IR）较高（p=0.037），胰岛素（p=0.037），NC(p=0.004),和血浆致动脉粥样硬化指数(AIP)(p=0.038)。WHR与NC相关(p=0.002；r=0.358)，葡萄糖(p=0.026;r=0.270);胰岛素(p=0.05;r=0.238);HOMA-IR(p=0.01;r=0.3238),甘油三酯(p=0.006;r=329)和AIP(p=0.02;r=0.370)。
结论：建议在重度肥胖中与SAH相关的WHR的新截止点。
