METHODS: Cross-sectional study with 75 Brazilian women with severe obesity (mean age: 37,6 years; weight of 122 kg and body mass index (BMI) of 47,8 kg/m2). Height, weight, neck circumference (NC), hip (HC), waist (WC) and waist-to-hip ratio (WHR) were obtained. Blood samples were collected for lipid/glucose profile. The Receiver Operating Characteristic (ROC) was explored to define cut-off points for WHR based on SAH. Women were compared using the t-Student/Mann Whitney test. Pearson/Spearman correlations were performed, and the significance level was set at 5%.
RESULTS: The ROC curve indicated that WHR ≥0.92 best predicted SAH. The group with WHR ≥0.92 had higher Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) (p = 0.037), insulin (p = 0.037), NC (p = 0.004), and Atherogenic Index of Plasma (AIP) (p = 0.038). WHR correlated with NC (p = 0.002; r = 0.358), glucose (p = 0.026; r = 0.270); insulin (p = 0.05; r = 0.238); HOMA-IR (p = 0.01; r = 0.3238), triglycerides (p = 0.006; r = 329) and AIP (p = 0.02; r = 0.370).
CONCLUSIONS: A new cut-off point for WHR related to SAH in severe obesity is suggested.
方法:对75名巴西重度肥胖妇女进行横断面研究(平均年龄:37,6岁;体重为122kg,体重指数(BMI)为47,8kg/m2)。高度,体重,颈围(NC),髋部(HC),获得腰围(WC)和腰臀比(WHR)。收集血液样品用于脂质/葡萄糖概况。探索接收器工作特性(ROC)以基于SAH定义WHR的截止点。使用t-Student/MannWhitney测试比较女性。进行了Pearson/Spearman相关性,显著性水平设定为5%。
结果:ROC曲线表明WHR≥0.92最佳预测SAH。WHR≥0.92组的胰岛素抵抗稳态模型评估(HOMA-IR)较高(p=0.037),胰岛素(p=0.037),NC(p=0.004),和血浆致动脉粥样硬化指数(AIP)(p=0.038)。WHR与NC相关(p=0.002;r=0.358),葡萄糖(p=0.026;r=0.270);胰岛素(p=0.05;r=0.238);HOMA-IR(p=0.01;r=0.3238),甘油三酯(p=0.006;r=329)和AIP(p=0.02;r=0.370)。
结论:建议在重度肥胖中与SAH相关的WHR的新截止点。