METHODS: This study included 448 patients with PCOS: 260 (58.0%) with phenotype A, 119 (26.6%) with phenotype B, 38 (8.5%) with phenotype C and 31 (6.9%) with phenotype D.
RESULTS: TAb positivity was detected in 90/448 patients (20.1%) and was statistically significant higher (p = 0.03) in the grouped phenotypes A-B (83/379, 21.9%) than in phenotypes C-D (7/69, 10.1%). Positive anti-thyroglobulin antibodies (TgAb) were detected in 74/448 (16.5%) patients and positive anti-thyroperoxidase antibodies (TPOAb) in 66/448 (14.7%) patients. Both TgAb and TPOAb positivity was higher but not statistically significant in phenotype A-B than phenotype C-D. High titer TgAb (> 100 UI/ml) frequency was significantly higher (p = 0.005) in grouped phenotypes A-B (39/379, 10.3%) than in phenotypes C-D (0/69, 0.0%), while no significant difference was observed for low titer TgAb (≤ 100 UI/ml). According to a binary logistic regression analysis hypothyroidism was significantly associated with TAb positivity (OR 4.19; CI 2.25-7.79; p < 0.01) but not with PCOS phenotype. Androgen profile was not associated with TAb positivity.
CONCLUSIONS: A higher frequency of positive TAb and of high titer TgAb and TPOAb have been detected in PCOS women with phenotypes A and B, probably in relation to the greater imbalances between estrogen and progesterone levels present in these phenotypes.
方法:这项研究包括448例PCOS患者:260例(58.0%)表型A,119(26.6%)表型为B,表型为C型的38例(8.5%)和表型为D型的31例(6.9%)。
结果:在90/448例患者(20.1%)中检测到TAb阳性,并且在统计学上(p=0.03)分组表型A-B(83/379,21.9%)高于表型C-D(7/69,10.1%)。74/448(16.5%)患者检测到抗甲状腺球蛋白抗体(TgAb)阳性,66/448(14.7%)患者检测到抗甲状腺过氧化物酶抗体(TPOAb)阳性。表型A-B中的TgAb和TPOAb阳性均高于表型C-D,但无统计学意义。高滴度TgAb(>100UI/ml)频率显着高于(p=0.005)在表型A-B(39/379,10.3%)比表型C-D(0/69,0.0%),而低滴度TgAb(≤100UI/ml)没有观察到显着差异。根据二元逻辑回归分析,甲状腺功能减退与TAb阳性显著相关(OR4.19;CI2.25-7.79;p<0.01),但与PCOS表型无关。雄激素谱与TAb阳性无关。
结论:在具有表型A和B的PCOS女性中检测到更高频率的Tab阳性和高滴度的TgAb和TPOAb,可能与这些表型中存在的雌激素和孕激素水平之间的更大失衡有关。