Abstract：
OBJECTIVE: Polycystic ovary syndrome (PCOS) has been associated with Hashimoto\'s thyroiditis (HT) and 4 phenotypes have been described in this syndrome. The aim of this work was to investigate the frequency of anti-thyroid antibodies (TAb) and thyroid function in the 4 phenotypes of PCOS.
METHODS: This study included 448 patients with PCOS: 260 (58.0%) with phenotype A, 119 (26.6%) with phenotype B, 38 (8.5%) with phenotype C and 31 (6.9%) with phenotype D.
RESULTS: TAb positivity was detected in 90/448 patients (20.1%) and was statistically significant higher (p = 0.03) in the grouped phenotypes A-B (83/379, 21.9%) than in phenotypes C-D (7/69, 10.1%). Positive anti-thyroglobulin antibodies (TgAb) were detected in 74/448 (16.5%) patients and positive anti-thyroperoxidase antibodies (TPOAb) in 66/448 (14.7%) patients. Both TgAb and TPOAb positivity was higher but not statistically significant in phenotype A-B than phenotype C-D. High titer TgAb (> 100 UI/ml) frequency was significantly higher (p = 0.005) in grouped phenotypes A-B (39/379, 10.3%) than in phenotypes C-D (0/69, 0.0%), while no significant difference was observed for low titer TgAb (≤ 100 UI/ml). According to a binary logistic regression analysis hypothyroidism was significantly associated with TAb positivity (OR 4.19; CI 2.25-7.79; p < 0.01) but not with PCOS phenotype. Androgen profile was not associated with TAb positivity.
CONCLUSIONS: A higher frequency of positive TAb and of high titer TgAb and TPOAb have been detected in PCOS women with phenotypes A and B, probably in relation to the greater imbalances between estrogen and progesterone levels present in these phenotypes.
METHODS: This study included 448 patients with PCOS: 260 (58.0%) with phenotype A, 119 (26.6%) with phenotype B, 38 (8.5%) with phenotype C and 31 (6.9%) with phenotype D.
RESULTS: TAb positivity was detected in 90/448 patients (20.1%) and was statistically significant higher (p = 0.03) in the grouped phenotypes A-B (83/379, 21.9%) than in phenotypes C-D (7/69, 10.1%). Positive anti-thyroglobulin antibodies (TgAb) were detected in 74/448 (16.5%) patients and positive anti-thyroperoxidase antibodies (TPOAb) in 66/448 (14.7%) patients. Both TgAb and TPOAb positivity was higher but not statistically significant in phenotype A-B than phenotype C-D. High titer TgAb (> 100 UI/ml) frequency was significantly higher (p = 0.005) in grouped phenotypes A-B (39/379, 10.3%) than in phenotypes C-D (0/69, 0.0%), while no significant difference was observed for low titer TgAb (≤ 100 UI/ml). According to a binary logistic regression analysis hypothyroidism was significantly associated with TAb positivity (OR 4.19; CI 2.25-7.79; p < 0.01) but not with PCOS phenotype. Androgen profile was not associated with TAb positivity.
CONCLUSIONS: A higher frequency of positive TAb and of high titer TgAb and TPOAb have been detected in PCOS women with phenotypes A and B, probably in relation to the greater imbalances between estrogen and progesterone levels present in these phenotypes.
摘要：
目的：多囊卵巢综合征（PCOS）与桥本甲状腺炎（HT）相关，并在该综合征中描述了4种表型。这项工作的目的是研究PCOS的4种表型中抗甲状腺抗体（TAb）的频率和甲状腺功能。
方法：这项研究包括448例PCOS患者：260例（58.0％）表型A，119（26.6%）表型为B，表型为C型的38例（8.5％）和表型为D型的31例（6.9％）。
结果：在90/448例患者（20.1％）中检测到TAb阳性，并且在统计学上（p=0.03）分组表型A-B（83/379，21.9％）高于表型C-D（7/69，10.1％）。74/448（16.5％）患者检测到抗甲状腺球蛋白抗体（TgAb）阳性，66/448（14.7％）患者检测到抗甲状腺过氧化物酶抗体（TPOAb）阳性。表型A-B中的TgAb和TPOAb阳性均高于表型C-D，但无统计学意义。高滴度TgAb（>100UI/ml）频率显着高于（p=0.005）在表型A-B（39/379，10.3％）比表型C-D（0/69，0.0％），而低滴度TgAb（≤100UI/ml）没有观察到显着差异。根据二元逻辑回归分析，甲状腺功能减退与TAb阳性显著相关(OR4.19;CI2.25-7.79;p<0.01)，但与PCOS表型无关。雄激素谱与TAb阳性无关。
结论：在具有表型A和B的PCOS女性中检测到更高频率的Tab阳性和高滴度的TgAb和TPOAb，可能与这些表型中存在的雌激素和孕激素水平之间的更大失衡有关。
方法：这项研究包括448例PCOS患者：260例（58.0％）表型A，119（26.6%）表型为B，表型为C型的38例（8.5％）和表型为D型的31例（6.9％）。
结果：在90/448例患者（20.1％）中检测到TAb阳性，并且在统计学上（p=0.03）分组表型A-B（83/379，21.9％）高于表型C-D（7/69，10.1％）。74/448（16.5％）患者检测到抗甲状腺球蛋白抗体（TgAb）阳性，66/448（14.7％）患者检测到抗甲状腺过氧化物酶抗体（TPOAb）阳性。表型A-B中的TgAb和TPOAb阳性均高于表型C-D，但无统计学意义。高滴度TgAb（>100UI/ml）频率显着高于（p=0.005）在表型A-B（39/379，10.3％）比表型C-D（0/69，0.0％），而低滴度TgAb（≤100UI/ml）没有观察到显着差异。根据二元逻辑回归分析，甲状腺功能减退与TAb阳性显著相关(OR4.19;CI2.25-7.79;p<0.01)，但与PCOS表型无关。雄激素谱与TAb阳性无关。
结论：在具有表型A和B的PCOS女性中检测到更高频率的Tab阳性和高滴度的TgAb和TPOAb，可能与这些表型中存在的雌激素和孕激素水平之间的更大失衡有关。
