PDF(Pubmed)
Abstract：
OBJECTIVE: The present investigation evaluates clinical uses and roles of platelet rich plasma in the management of vetrebrogenic and discogenic mediated pain states.
RESULTS: Back pain is a common and significant condition that affects millions of people around the world. The cause of back pain is often complex and multifactorial, with discogenic and vertebrogenic pain being two subtypes of back pain. Currently, there are numerous methods and modalities in which back pain is managed and treated such as physical therapy, electrical nerve stimulation, pharmacotherapies, and platelet-rich plasma. To conduct this systematic review, the authors used the keywords \"platelet-rich plasma\", \"vertebrogenic pain\", and \"discogenic pain\", on PubMed, EuroPMC, Who ICTRP, and clinicaltrials.gov to better elucidate the role of this treatment method for combating vertebrogenic and discogenic back pain. In recent decades, there has been a rise in popularity of the use of platelet-rich plasma for the treatment of numerous musculoskeletal conditions. Related to high concentration of platelets, growth factors, cytokines, and chemokines, platelet-rich plasma is effective in reducing pain related symptoms and in the treatment of back pain. Platelet-rich plasma use has evolved and gained popularity for pain related conditions, including vertebrogenic and discogenic back pain. Additional well-designed studies are warranted in the future to better determine best practice strategies to provide future clinicians with a solid foundation of evidence to make advancements with regenerative medical therapies such as platelet-rich plasma.
RESULTS: Back pain is a common and significant condition that affects millions of people around the world. The cause of back pain is often complex and multifactorial, with discogenic and vertebrogenic pain being two subtypes of back pain. Currently, there are numerous methods and modalities in which back pain is managed and treated such as physical therapy, electrical nerve stimulation, pharmacotherapies, and platelet-rich plasma. To conduct this systematic review, the authors used the keywords \"platelet-rich plasma\", \"vertebrogenic pain\", and \"discogenic pain\", on PubMed, EuroPMC, Who ICTRP, and clinicaltrials.gov to better elucidate the role of this treatment method for combating vertebrogenic and discogenic back pain. In recent decades, there has been a rise in popularity of the use of platelet-rich plasma for the treatment of numerous musculoskeletal conditions. Related to high concentration of platelets, growth factors, cytokines, and chemokines, platelet-rich plasma is effective in reducing pain related symptoms and in the treatment of back pain. Platelet-rich plasma use has evolved and gained popularity for pain related conditions, including vertebrogenic and discogenic back pain. Additional well-designed studies are warranted in the future to better determine best practice strategies to provide future clinicians with a solid foundation of evidence to make advancements with regenerative medical therapies such as platelet-rich plasma.
摘要：
目的：本研究评估了富血小板血浆在治疗肿瘤源性和盘源性介导的疼痛状态中的临床应用和作用。
结果：背痛是一种常见且重要的疾病，影响着全世界数百万人。背痛的原因通常是复杂和多方面的，椎间盘源性和椎体源性疼痛是背痛的两种亚型。目前,有许多方法和方式，其中背痛的管理和治疗，如物理治疗，神经电刺激,药物疗法,和富含血小板的血浆.为了进行系统的审查，作者使用了关键词“富含血小板的血浆”，“脊椎源性疼痛”，和“椎间盘源性疼痛”，在PubMed上,EuroPMC,谁ICTRP，和clinicaltries.gov更好地阐明这种治疗方法在对抗椎体源性和椎间盘源性背痛中的作用。近几十年来,使用富含血小板的血浆治疗许多肌肉骨骼疾病的流行度越来越高。与高浓度的血小板有关,生长因子，细胞因子,和趋化因子，富含血小板的血浆可有效减轻疼痛相关症状和治疗背痛。富含血小板的血浆使用已经发展起来，并在疼痛相关疾病中得到了普及，包括椎体源性和椎间盘源性背痛。未来需要更多精心设计的研究，以更好地确定最佳实践策略，为未来的临床医生提供坚实的证据基础，以促进再生医学疗法，如富血小板血浆。
结果：背痛是一种常见且重要的疾病，影响着全世界数百万人。背痛的原因通常是复杂和多方面的，椎间盘源性和椎体源性疼痛是背痛的两种亚型。目前,有许多方法和方式，其中背痛的管理和治疗，如物理治疗，神经电刺激,药物疗法,和富含血小板的血浆.为了进行系统的审查，作者使用了关键词“富含血小板的血浆”，“脊椎源性疼痛”，和“椎间盘源性疼痛”，在PubMed上,EuroPMC,谁ICTRP，和clinicaltries.gov更好地阐明这种治疗方法在对抗椎体源性和椎间盘源性背痛中的作用。近几十年来,使用富含血小板的血浆治疗许多肌肉骨骼疾病的流行度越来越高。与高浓度的血小板有关,生长因子，细胞因子,和趋化因子，富含血小板的血浆可有效减轻疼痛相关症状和治疗背痛。富含血小板的血浆使用已经发展起来，并在疼痛相关疾病中得到了普及，包括椎体源性和椎间盘源性背痛。未来需要更多精心设计的研究，以更好地确定最佳实践策略，为未来的临床医生提供坚实的证据基础，以促进再生医学疗法，如富血小板血浆。
