Abstract：
The microbiome is intricately linked to the development of psoriasis, serving as both a potential cause and consequence of the psoriatic process. In recent years, there has been growing interest among psoriasis researchers in exploring how psoriasis treatments affect the skin and gut microbiome. However, a comprehensive evaluation of the impact of modern treatment approaches on the microbiome has yet to be conducted. In this systematic review, we analyze studies investigating alterations in the skin and gut microbiome resulting from psoriasis treatment, aiming to understand how current therapies influence the role of the microbiome in psoriasis development. The systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. PubMed and Scopus databases were searched for eligible studies from the inception dates until July 5, 2023. Study selection, data extraction, and risk of bias assessment were carried out by three overlapping pairs of reviewers, resolving any disagreements through consensus. Our analysis of various treatments, including biologics, conventional medications, phototherapy, and probiotics, reveals significant shifts in microbial diversity and abundance. Importantly, favorable treatment outcomes are associated with microbiota alterations that approach those observed in healthy individuals. While the studies reviewed exhibit varying degrees of bias, underscoring the need for further research, this review supports the potential of microbiome modulation as both a preventive and therapeutic strategy for psoriasis patients. The findings underscore the importance of personalized therapeutic approaches, recognizing the profound impact of treatment on the microbiome. They also highlight the promise of probiotics, prebiotics, and dietary interventions in psoriasis management.
摘要：
微生物组与牛皮癣的发展有着错综复杂的联系，作为银屑病过程的潜在原因和结果。近年来,牛皮癣研究人员对探索牛皮癣治疗如何影响皮肤和肠道微生物组越来越感兴趣。然而,尚未对现代治疗方法对微生物组的影响进行全面评估。在这次系统审查中，我们分析了研究牛皮癣治疗引起的皮肤和肠道微生物组变化的研究，旨在了解当前的治疗方法如何影响微生物组在牛皮癣发展中的作用。根据系统评价和荟萃分析（PRISMA）指南的首选报告项目进行系统评价。从开始日期到2023年7月5日，在PubMed和Scopus数据库中搜索合格的研究。研究选择，数据提取,偏见风险评估由三对重叠的审阅者进行，通过协商一致解决任何分歧。我们对各种治疗方法的分析，包括生物制品，常规药物,光疗,和益生菌，揭示了微生物多样性和丰度的显著变化。重要的是,良好的治疗结果与接近健康个体的微生物群改变相关.虽然审查的研究表现出不同程度的偏见，强调需要进一步研究，这篇综述支持微生物组调节作为银屑病患者的预防和治疗策略的潜力.这些发现强调了个性化治疗方法的重要性，认识到治疗对微生物组的深远影响。他们还强调了益生菌的前景，益生元,和牛皮癣管理中的饮食干预。
