Abstract：
PP mesh is a widely used prosthetic material in hernia repair. However, visceral adhesion is one of the worst complications of this operation. Hence, an anti-adhesive PP mesh is developed by coating porous polyvinyl alcohol (PVA) hydrogel on PP surface via freezing-thawing process method. The compressive modulus of porous PVA hydrogel coating is first regulated by the addition of porogen sodium bicarbonate (NaHCO3) at various quality ratios with PVA. As expected, the porous hydrogel coating displayed modulus more closely resembling that of native abdominal wall tissue. In vitro tests demonstrate the modified PP mesh show superior coating stability, excellent hemocompatibility, and good cytocompatibility. In vivo experiments illustrate that PP mesh coated by the PVA4 hydrogel that mimicked the modulus of native abdominal wall could prevent adhesion effectively. Based on this, the rapamycin (RPM) is loaded into the porous PVA4 hydrogel coating to further improve anti-adhesive property of PP mesh. The Hematoxylin and eosin (H&E) and Masson trichrome (MT) staining results verified that the resulting mesh could alleviate the inflammation response and reduce the deposition of collagen around the implantation zone. The biomimetic mechanical property and anti-adhesive property of modified PP mesh make it a valuable candidate for application in hernioplasty.
摘要：
PP网片是一种广泛用于疝修补术的假体材料。然而,内脏粘连是该手术最严重的并发症之一。因此，通过冻融工艺方法在聚丙烯表面涂覆多孔聚乙烯醇（PVA）水凝胶，开发了一种抗粘连的聚丙烯网。多孔PVA水凝胶涂层的压缩模量首先通过以与PVA的各种质量比添加致孔剂碳酸氢钠（NaHCO3）来调节。不出所料,多孔水凝胶涂层的模量更接近天然腹壁组织。体外试验证明改性PP网片显示出优越的涂层稳固性，优良的血液相容性，和良好的细胞相容性。体内实验表明，模仿天然腹壁模量的PVA4水凝胶涂覆的PP网可以有效防止粘连。基于此,将雷帕霉素（RPM）加载到多孔PVA4水凝胶涂层中，以进一步提高PP网的抗粘附性能。苏木精和伊红（H＆E）和马森三色（MT）染色结果证实，所得网状物可以减轻炎症反应并减少胶原在植入区周围的沉积。改性PP网片的仿生力学性能和抗粘连性能使其成为有价值的疝修补术候选材料。本文受版权保护。保留所有权利。
