Abstract：
The FtsEX membrane complex constitutes an essential component of the ABC transporter superfamily, widely distributed among bacterial species. It governs peptidoglycan degradation for cell division, acting as a signal transmitter rather than a substrate transporter. Through the ATPase activity of FtsE, it facilitates signal transmission from the cytosol across the membrane to the periplasm, activating associated peptidoglycan hydrolases. This review concentrates on the latest structural advancements elucidating the architecture of the FtsEX complex and its interplay with lytic enzymes or regulatory counterparts. The revealed three-dimensional structures unveil a landscape wherein a precise array of intermolecular interactions, preserved across diverse bacterial species, afford meticulous spatial and temporal control over the cell division process.
摘要：
FtsEX膜复合物构成了ABC转运蛋白超家族的重要组成部分，在细菌种类中广泛分布。它控制肽聚糖降解以进行细胞分裂，充当信号发射器而不是衬底运输机。通过ATPase活性的FtsE，它促进信号从细胞质穿过膜传递到周质，激活相关的肽聚糖水解酶。这篇综述集中于最新的结构进展，阐明了FtsEX复合物的结构及其与裂解酶或监管对应物的相互作用。揭示的三维结构揭示了一个精确的分子间相互作用阵列的景观，保存在不同的细菌物种中，对细胞分裂过程提供细致的空间和时间控制。
