Abstract：
In the pursuit of achieving better therapeutic outcomes in the treatment of HIV, innovative drug delivery strategies have been extensively explored. Mannose receptors, which are primarily found on macrophages and dendritic cells, offer promising targets for drug delivery due to their involvement in HIV pathogenesis. This review article comprehensively evaluates recent drug delivery system advancements targeting the mannose receptor. We have systematically described recent developments in creating and utilizing drug delivery platforms, including nanoparticles, liposomes, micelles, noisomes, dendrimers, and other nanocarrier systems targeted at the mannose receptor. These strategies aim to enhance drug delivery specificity, bioavailability, and therapeutic efficacy while decreasing off-target effects and systemic toxicity. Furthermore, the article delves into how mannose receptors and HIV interact, highlighting the potential for exploiting this interaction to enhance drug delivery to infected cells. The review covers essential topics, such as the rational design of nanocarriers for mannose receptor recognition, the impact of physicochemical properties on drug delivery performance, and how targeted delivery affects the pharmacokinetics and pharmacodynamics of anti-HIV agents. The challenges of these novel strategies, including immunogenicity, stability, and scalability, and future research directions in this rapidly growing area are discussed. The knowledge synthesis presented in this review underscores the potential of mannose receptor-based targeted drug delivery as a promising avenue for advancing HIV treatment. By leveraging the unique properties of mannose receptors, researchers can design drug delivery systems that cater to individual needs, overcome existing limitations, and create more effective and patient-friendly treatments in the ongoing fight against HIV/AIDS.
摘要：
为了在治疗艾滋病毒方面取得更好的治疗效果，创新的药物输送策略已被广泛探索。甘露糖受体,主要在巨噬细胞和树突状细胞上发现，由于它们参与HIV发病机制，为药物递送提供了有希望的靶标。本文综合评价了近年来针对甘露糖受体的给药系统的研究进展。我们已经系统地描述了在创建和利用药物输送平台方面的最新进展，包括纳米粒子,脂质体，胶束，噪声，树枝状聚合物,和其他靶向甘露糖受体的纳米载体系统。这些策略旨在增强药物递送特异性，生物利用度，和治疗效果，同时减少脱靶效应和全身毒性。此外，这篇文章探讨了甘露糖受体和HIV是如何相互作用的，强调了利用这种相互作用增强药物向受感染细胞输送的潜力。审查涵盖了基本主题，例如用于甘露糖受体识别的纳米载体的合理设计，理化性质对药物输送性能的影响，以及靶向递送如何影响抗HIV药物的药代动力学和药效学。这些新颖策略的挑战，包括免疫原性，稳定性,和可扩展性，并讨论了这一快速增长领域未来的研究方向。这篇综述中提出的知识综合强调了基于甘露糖受体的靶向药物递送作为推进HIV治疗的有希望的途径的潜力。通过利用甘露糖受体的独特特性，研究人员可以设计满足个人需求的药物输送系统，克服现有的限制，并在正在进行的防治艾滋病毒/艾滋病的斗争中创造更有效和对患者友好的治疗方法。
