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Abstract：
BACKGROUND: Prior research has established the effectiveness of magnesium in relieving postoperative pain. This article aims to evaluate magnesium sulfate for perioperative analgesia in adults undergoing general abdominal surgery under general anesthesia.
OBJECTIVE: The primary aim was to assess pain scores at 6 and 24 hours postoperatively in patients receiving magnesium sulfate vs. the control group. Secondary outcomes were postoperative opioid consumption, perioperative complications, and time to rescue analgesia.
METHODS: A comprehensive database search identified studies comparing magnesium sulfate with control in adults undergoing general anesthesia for general abdominal surgery. Using random-effects models, data were presented as mean ± Standard Deviation (SD) or Odds Ratios (OR) with corresponding 95% Confidence Intervals (95% CI). A two-sided p-value < 0.05 was considered statistically significant.
RESULTS: In total, 31 studies involving 1762 participants met the inclusion criteria. The magnesium group showed significantly lower postoperative pain scores at both early (within six hours) and late (up to 24 hours) time points compared to the control group. The early mean score was 3.1 ± 1.4 vs. 4.2 ± 2.3, and the late mean score was 2.3 ± 1.1 vs. 2.7 ± 1.5, resulting in an overall Mean Difference (MD) of -0.72; 95% CI -0.99, -0.44; p < 0.00001. The magnesium group was associated with lower rates of postoperative opioid consumption and shivering and had a longer time to first analgesia administration compared to the saline control group.
CONCLUSIONS: Magnesium sulfate administration was linked to reduced postoperative pain and opioid consumption following general abdominal surgery.
OBJECTIVE: The primary aim was to assess pain scores at 6 and 24 hours postoperatively in patients receiving magnesium sulfate vs. the control group. Secondary outcomes were postoperative opioid consumption, perioperative complications, and time to rescue analgesia.
METHODS: A comprehensive database search identified studies comparing magnesium sulfate with control in adults undergoing general anesthesia for general abdominal surgery. Using random-effects models, data were presented as mean ± Standard Deviation (SD) or Odds Ratios (OR) with corresponding 95% Confidence Intervals (95% CI). A two-sided p-value < 0.05 was considered statistically significant.
RESULTS: In total, 31 studies involving 1762 participants met the inclusion criteria. The magnesium group showed significantly lower postoperative pain scores at both early (within six hours) and late (up to 24 hours) time points compared to the control group. The early mean score was 3.1 ± 1.4 vs. 4.2 ± 2.3, and the late mean score was 2.3 ± 1.1 vs. 2.7 ± 1.5, resulting in an overall Mean Difference (MD) of -0.72; 95% CI -0.99, -0.44; p < 0.00001. The magnesium group was associated with lower rates of postoperative opioid consumption and shivering and had a longer time to first analgesia administration compared to the saline control group.
CONCLUSIONS: Magnesium sulfate administration was linked to reduced postoperative pain and opioid consumption following general abdominal surgery.
摘要：
背景：先前的研究已经确定了镁在缓解术后疼痛方面的有效性。本文旨在评价硫酸镁在全身麻醉下成人腹部手术围手术期的镇痛效果。
目的：主要目的是评估接受硫酸镁治疗的患者术后6小时和24小时的疼痛评分。对照组。次要结果是术后阿片类药物的消耗，围手术期并发症,和时间来挽救镇痛。
方法：一项全面的数据库搜索确定了在接受全身麻醉的成人腹部手术中比较硫酸镁与对照组的研究。使用随机效应模型，数据以平均值±标准差(SD)或赔率比(OR)表示,对应95%置信区间(95%CI).双侧P值<0.05被认为是统计学上显著的。
结果：总计，涉及1762名参与者的31项研究符合纳入标准。与对照组相比，镁组在早期（6小时内）和晚期（长达24小时）时间点的术后疼痛评分均显着降低。早期平均得分为3.1±1.4。4.2±2.3，后期平均得分为2.3±1.1。2.7±1.5，导致整体平均差（MD）为-0.72；95％CI-0.99，-0.44；p<0.00001。与生理盐水对照组相比，镁组术后阿片类药物消耗和寒战的发生率较低，首次镇痛的时间更长。
结论：给予硫酸镁与普通腹部手术后的术后疼痛和阿片类药物消耗减少有关。
目的：主要目的是评估接受硫酸镁治疗的患者术后6小时和24小时的疼痛评分。对照组。次要结果是术后阿片类药物的消耗，围手术期并发症,和时间来挽救镇痛。
方法：一项全面的数据库搜索确定了在接受全身麻醉的成人腹部手术中比较硫酸镁与对照组的研究。使用随机效应模型，数据以平均值±标准差(SD)或赔率比(OR)表示,对应95%置信区间(95%CI).双侧P值<0.05被认为是统计学上显著的。
结果：总计，涉及1762名参与者的31项研究符合纳入标准。与对照组相比，镁组在早期（6小时内）和晚期（长达24小时）时间点的术后疼痛评分均显着降低。早期平均得分为3.1±1.4。4.2±2.3，后期平均得分为2.3±1.1。2.7±1.5，导致整体平均差（MD）为-0.72；95％CI-0.99，-0.44；p<0.00001。与生理盐水对照组相比，镁组术后阿片类药物消耗和寒战的发生率较低，首次镇痛的时间更长。
结论：给予硫酸镁与普通腹部手术后的术后疼痛和阿片类药物消耗减少有关。
