关键词: Cancer theranostics Drug delivery NBs Nanomedicine Precision medicine Targeted therapy Tumor imaging oxygen NBs

Mesh : Humans Neoplasms / therapy diagnosis drug therapy Theranostic Nanomedicine / methods trends Animals Drug Delivery Systems / methods trends Nanoparticles / chemistry administration & dosage Antineoplastic Agents / administration & dosage therapeutic use Precision Medicine / methods trends Microbubbles

来  源:   DOI:10.1016/j.bcp.2024.116341

Abstract:
Maximizing treatment efficacy and forecasting patient prognosis in cancer necessitates the strategic use of targeted therapy, coupled with the prompt precise detection of malignant tumors. Theutilizationof gaseous systems as an adaptable platform for creating nanobubbles (NBs) has garnered significant attention as theranostics, which involve combining contrast chemicals typically used for imaging with pharmaceuticals to diagnose and treattumorssynergistically in apersonalizedmanner for each patient. This review specifically examines the utilization of oxygen NBsplatforms as a theranostic weapon in the field of oncology. We thoroughly examine the key factors that impact the effectiveness of NBs preparations and the consequences of these treatment methods. This review extensively examines recent advancements in composition schemes, advanced developments in pre-clinical phases, and other groundbreaking inventions in the area of NBs. Moreover, this review offers a thorough examination of the optimistic future possibilities, addressing prospective methods for improvement and incorporation into widely accepted therapeutic practices. As we explore the ever-changing field of cancer theranostics, the incorporation of oxygen NBs appears as a promising development, providing new opportunities for precision medicine and marking a revolutionary age in cancer research and therapy.
摘要:
最大限度地提高癌症治疗效果和预测患者预后需要战略性地使用靶向治疗。再加上恶性肿瘤的快速精确检测。气体系统作为产生纳米气泡(NBs)的适应性平台的利用已经引起了人们的极大关注,其中涉及将通常用于成像的造影剂与药物相结合,以不同的方式对每位患者进行协同诊断和治疗。这篇综述专门研究了氧气NBs平台作为肿瘤学领域的治疗治疗武器的利用。我们彻底检查了影响NBs制剂有效性的关键因素以及这些治疗方法的后果。这篇综述广泛考察了构图方案的最新进展,临床前阶段的先进发展,以及NB领域的其他开创性发明。此外,这篇评论对乐观的未来可能性进行了彻底的审查,解决改善和纳入广泛接受的治疗实践的前瞻性方法。当我们探索不断变化的癌症治疗领域时,氧NBs的掺入似乎是一个有希望的发展,为精准医学提供新的机会,标志着癌症研究和治疗的革命性时代。
公众号