PDF(Pubmed)
Abstract：
BACKGROUND: Nasopharyngeal carcinoma has a high incidence in East and Southeast Asia, often with distant metastasis. However, leptomeningeal metastasis (LM) is extremely rare and usually has a poor prognosis. This paper reports the clinical treatment of a patient with meningeal metastasis of nasopharyngeal carcinoma (NPC) in order to improve the clinician\'s understanding of the disease. Early diagnosis of the disease can alleviate the pain of patients and prolong their survival time.
METHODS: We report the case of a 55-year-old female with a history of NPC with LM. Brain magnetic resonance imaging showed temporal lobe enhancement, peripheral edema, and enhancement of the adjacent meninges. Cerebrospinal fluid cytology suggests the presence of malignant tumor cells.
METHODS: The patient was diagnosed with LM from NPC.
METHODS: The patients were regularly given targeted therapy with nimotuzumab, immunotherapy with karyolizumab, and lumbar intrathecal methotrexate chemotherapy and supportive treatment.
RESULTS: The patient had survived for 3 years since the diagnosis of LM and was in good condition and still under active antitumor treatment.
CONCLUSIONS: Leptomeningeal metastasis of NPC is a rare disease. Although there is currently no unified treatment plan, the neurological symptoms can still be controlled and the quality of life can be improved through active treatment.
METHODS: We report the case of a 55-year-old female with a history of NPC with LM. Brain magnetic resonance imaging showed temporal lobe enhancement, peripheral edema, and enhancement of the adjacent meninges. Cerebrospinal fluid cytology suggests the presence of malignant tumor cells.
METHODS: The patient was diagnosed with LM from NPC.
METHODS: The patients were regularly given targeted therapy with nimotuzumab, immunotherapy with karyolizumab, and lumbar intrathecal methotrexate chemotherapy and supportive treatment.
RESULTS: The patient had survived for 3 years since the diagnosis of LM and was in good condition and still under active antitumor treatment.
CONCLUSIONS: Leptomeningeal metastasis of NPC is a rare disease. Although there is currently no unified treatment plan, the neurological symptoms can still be controlled and the quality of life can be improved through active treatment.
摘要：
背景：鼻咽癌在东亚和东南亚发病率高，常伴有远处转移.然而,软脑膜转移（LM）极为罕见，通常预后不良。本文报告1例鼻咽癌脑膜转移患者的临床治疗情况,以提高临床医师对该病的认识。早期诊断可以减轻患者的痛苦，延长患者的生存时间。
方法：我们报告一例55岁女性，有LM伴NPC病史。脑磁共振成像显示颞叶增强，外周水肿,和增强相邻的脑膜。脑脊液细胞学检查提示存在恶性肿瘤细胞。
方法：患者被诊断为患有NPC的LM。
方法：患者定期给予尼妥珠单抗靶向治疗，karyolizumab免疫疗法，和腰椎鞘内注射甲氨蝶呤化疗和支持治疗。
结果：患者自LM诊断后存活3年，情况良好，仍在积极的抗肿瘤治疗中。
结论：鼻咽癌脑膜转移是一种罕见的疾病。虽然目前没有统一的治疗方案,通过积极治疗，神经系统症状仍然可以得到控制，生活质量可以得到改善。
方法：我们报告一例55岁女性，有LM伴NPC病史。脑磁共振成像显示颞叶增强，外周水肿,和增强相邻的脑膜。脑脊液细胞学检查提示存在恶性肿瘤细胞。
方法：患者被诊断为患有NPC的LM。
方法：患者定期给予尼妥珠单抗靶向治疗，karyolizumab免疫疗法，和腰椎鞘内注射甲氨蝶呤化疗和支持治疗。
结果：患者自LM诊断后存活3年，情况良好，仍在积极的抗肿瘤治疗中。
结论：鼻咽癌脑膜转移是一种罕见的疾病。虽然目前没有统一的治疗方案,通过积极治疗，神经系统症状仍然可以得到控制，生活质量可以得到改善。
