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Abstract：
BACKGROUND: The role of non-nitrogen-containing bisphosphonates (non-N-BPs) and nitrogen-containing bisphosphonates (N-BPs) in the treatment of atherosclerosis (AS) and vascular calcification (VC) is uncertain. This meta-analysis was conducted to evaluate the efficacy of non-N-BPs and N-BPs in the treatment of AS and VC.
METHODS: The PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, and Wanfang databases were searched from their inception to July 5th, 2023. Eligible studies comparing bisphosphonates (BPs) versus no BPs in the treatment of AS and VC were included. The data were analyzed using Review Manager Version 5.3.
RESULTS: Seventeen studies were included in this meta-analysis. Twelve were randomized control trials (RCTs), and 5 were nonrandomized studies. Overall, 813 patients were included in the BPs group, and 821 patients were included in the no BPs group. Compared with no BP treatment, non-N-BP or N-BP treatment did not affect serum calcium (P > .05), phosphorus (P > .05) or parathyroid hormone (PTH) levels (P > .05). Regarding the effect on serum lipids, non-N-BPs decreased the serum total cholesterol (TC) level (P < .05) and increased the serum triglyceride (TG) level (P < .01) but did not affect the serum low-density lipoprotein cholesterol (LDL-C) level (P > .05). N-BPs did not affect serum TC (P > .05), TG (P > .05) or LDL-C levels (P > .05). Regarding the effect on AS, non-N-BPs did not have a beneficial effect (P > .05). N-BPs had a beneficial effect on AS, including reducing the intima-media thickness (IMT) (P < .05) and plaque area (P < .01). For the effect on VC, non-N-BPs had a beneficial effect (P < .01), but N-BPs did not have a beneficial effect (P > .05).
CONCLUSIONS: Non-N-BPs and N-BPs did not affect serum calcium, phosphorus or PTH levels. Non-N-BPs decreased serum TC levels and increased serum TG levels. N-BPs did not affect serum lipid levels. Non-N-BPs had a beneficial effect on VC, and N-BPs had a beneficial effect on AS.
METHODS: The PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, and Wanfang databases were searched from their inception to July 5th, 2023. Eligible studies comparing bisphosphonates (BPs) versus no BPs in the treatment of AS and VC were included. The data were analyzed using Review Manager Version 5.3.
RESULTS: Seventeen studies were included in this meta-analysis. Twelve were randomized control trials (RCTs), and 5 were nonrandomized studies. Overall, 813 patients were included in the BPs group, and 821 patients were included in the no BPs group. Compared with no BP treatment, non-N-BP or N-BP treatment did not affect serum calcium (P > .05), phosphorus (P > .05) or parathyroid hormone (PTH) levels (P > .05). Regarding the effect on serum lipids, non-N-BPs decreased the serum total cholesterol (TC) level (P < .05) and increased the serum triglyceride (TG) level (P < .01) but did not affect the serum low-density lipoprotein cholesterol (LDL-C) level (P > .05). N-BPs did not affect serum TC (P > .05), TG (P > .05) or LDL-C levels (P > .05). Regarding the effect on AS, non-N-BPs did not have a beneficial effect (P > .05). N-BPs had a beneficial effect on AS, including reducing the intima-media thickness (IMT) (P < .05) and plaque area (P < .01). For the effect on VC, non-N-BPs had a beneficial effect (P < .01), but N-BPs did not have a beneficial effect (P > .05).
CONCLUSIONS: Non-N-BPs and N-BPs did not affect serum calcium, phosphorus or PTH levels. Non-N-BPs decreased serum TC levels and increased serum TG levels. N-BPs did not affect serum lipid levels. Non-N-BPs had a beneficial effect on VC, and N-BPs had a beneficial effect on AS.
摘要：
背景：非含氮双膦酸盐（非N-BP）和含氮双膦酸盐（N-BP）在治疗动脉粥样硬化（AS）和血管钙化（VC）中的作用尚不确定。这项荟萃分析旨在评估非N-BP和N-BP治疗AS和VC的疗效。
方法：PubMed，Embase,科克伦图书馆,中国国家知识基础设施，和万方数据库从成立到7月5日进行了搜索，2023年。纳入了比较双膦酸盐（BP）和无BP治疗AS和VC的合格研究。使用ReviewManager版本5.3分析数据。
结果：本荟萃分析包括17项研究。12项随机对照试验(RCTs)，5项为非随机研究.总的来说,BPs组包括813例患者，821例患者被纳入无BP组。与无BP治疗相比,非N-BP或N-BP治疗不影响血清钙（P>0.05），磷(P>.05)或甲状旁腺激素(PTH)水平(P>.05)。关于对血脂的影响，non-N-BPs降低血清总胆固醇（TC）水平（P<.05），升高血清甘油三酯（TG）水平（P<.01），但不影响血清低密度脂蛋白胆固醇（LDL-C）水平（P>.05）。N-BPs不影响血清TC（P>0.05），TG(P>.05)或LDL-C水平(P>.05)。关于对AS的影响，非N-BP没有有益效果（P>.05）。N-BP对AS有有益作用，包括减少内膜中层厚度（IMT）（P<.05）和斑块面积（P<.01）。对于VC的影响，非N-BP具有有益效果（P<0.01），但N-BP没有有益效果（P>.05）。
结论：非N-BP和N-BP不影响血清钙，磷或PTH水平。Non-N-BPs降低血清TC水平，升高血清TG水平。N-BP不影响血脂水平。非N-BP对VC有有益的影响，N-BP对AS有有益作用。
方法：PubMed，Embase,科克伦图书馆,中国国家知识基础设施，和万方数据库从成立到7月5日进行了搜索，2023年。纳入了比较双膦酸盐（BP）和无BP治疗AS和VC的合格研究。使用ReviewManager版本5.3分析数据。
结果：本荟萃分析包括17项研究。12项随机对照试验(RCTs)，5项为非随机研究.总的来说,BPs组包括813例患者，821例患者被纳入无BP组。与无BP治疗相比,非N-BP或N-BP治疗不影响血清钙（P>0.05），磷(P>.05)或甲状旁腺激素(PTH)水平(P>.05)。关于对血脂的影响，non-N-BPs降低血清总胆固醇（TC）水平（P<.05），升高血清甘油三酯（TG）水平（P<.01），但不影响血清低密度脂蛋白胆固醇（LDL-C）水平（P>.05）。N-BPs不影响血清TC（P>0.05），TG(P>.05)或LDL-C水平(P>.05)。关于对AS的影响，非N-BP没有有益效果（P>.05）。N-BP对AS有有益作用，包括减少内膜中层厚度（IMT）（P<.05）和斑块面积（P<.01）。对于VC的影响，非N-BP具有有益效果（P<0.01），但N-BP没有有益效果（P>.05）。
结论：非N-BP和N-BP不影响血清钙，磷或PTH水平。Non-N-BPs降低血清TC水平，升高血清TG水平。N-BP不影响血脂水平。非N-BP对VC有有益的影响，N-BP对AS有有益作用。
