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Abstract：
BACKGROUND: Numerous studies have investigated the association between CDH1 polymorphisms and gastric cancer (GC) risk. However, the results have been inconsistent and controversial. To further determine whether CDH1 polymorphisms increase the risk of GC, we conducted a meta-analysis by pooling the data.
METHODS: Relevant case-control studies were collected from PubMed, Embase, Web of Science and Cochrane databases up to January 7, 2024. Subsequently, odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of correlations. A sensitivity analysis was performed to evaluate the robustness and reliability of these included studies.
RESULTS: A total of 25 articles including 44 studies, were included in this meta-analysis, including 26 studies on rs16260, 6 studies on rs3743674, 7 studies on rs5030625, and 5 studies on rs1801552. The pooled results showed that rs16260 was remarkably associated with an increased GC risk of GC among Caucasians. Moreover, the rs5030625 variation dramatically enhanced GC predisposition in the Asian population. However, no evident correlations between CDH1 rs3743674 and rs1801552 polymorphisms and GC risk were observed.
CONCLUSIONS: Our findings suggested that CDH1 gene polymorphisms were significantly correlated with GC risk, especially in rs16260 and rs5030625 polymorphisms.
METHODS: Relevant case-control studies were collected from PubMed, Embase, Web of Science and Cochrane databases up to January 7, 2024. Subsequently, odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of correlations. A sensitivity analysis was performed to evaluate the robustness and reliability of these included studies.
RESULTS: A total of 25 articles including 44 studies, were included in this meta-analysis, including 26 studies on rs16260, 6 studies on rs3743674, 7 studies on rs5030625, and 5 studies on rs1801552. The pooled results showed that rs16260 was remarkably associated with an increased GC risk of GC among Caucasians. Moreover, the rs5030625 variation dramatically enhanced GC predisposition in the Asian population. However, no evident correlations between CDH1 rs3743674 and rs1801552 polymorphisms and GC risk were observed.
CONCLUSIONS: Our findings suggested that CDH1 gene polymorphisms were significantly correlated with GC risk, especially in rs16260 and rs5030625 polymorphisms.
摘要：
背景：许多研究已经调查了CDH1多态性与胃癌（GC）风险之间的关联。然而,结果一直不一致和有争议。为了进一步确定CDH1多态性是否增加GC的风险，我们通过汇集数据进行了荟萃分析.
方法：相关病例对照研究来自PubMed，Embase,截至2024年1月7日的WebofScience和Cochrane数据库。随后，使用具有95%置信区间(CIs)的比值比(ORs)评估相关性的强度.进行敏感性分析以评估这些纳入研究的稳健性和可靠性。
结果：共25篇文章，包括44项研究，被包括在这个荟萃分析中，其中rs16260研究26项,rs3743674研究6项,rs5030625研究7项,rs1801552研究5项。汇总结果显示，rs16260与高加索人中GC的GC风险增加显着相关。此外，rs5030625变异显着增强了亚洲人群的GC易感性。然而,未观察到CDH1rs3743674和rs1801552多态性与GC风险之间的明显相关性。
结论：我们的发现表明CDH1基因多态性与GC风险显著相关，尤其是rs16260和rs5030625多态性。
方法：相关病例对照研究来自PubMed，Embase,截至2024年1月7日的WebofScience和Cochrane数据库。随后，使用具有95%置信区间(CIs)的比值比(ORs)评估相关性的强度.进行敏感性分析以评估这些纳入研究的稳健性和可靠性。
结果：共25篇文章，包括44项研究，被包括在这个荟萃分析中，其中rs16260研究26项,rs3743674研究6项,rs5030625研究7项,rs1801552研究5项。汇总结果显示，rs16260与高加索人中GC的GC风险增加显着相关。此外，rs5030625变异显着增强了亚洲人群的GC易感性。然而,未观察到CDH1rs3743674和rs1801552多态性与GC风险之间的明显相关性。
结论：我们的发现表明CDH1基因多态性与GC风险显著相关，尤其是rs16260和rs5030625多态性。
