Abstract：
The high recurrence rate of hepatocellular carcinoma (HCC) and poor prognosis after medical treatment reflects the necessity to improve the current chemotherapy protocols, particularly drug delivery methods. Development of targeted and efficient drug delivery systems (DDSs), in all active, passive and stimuli-responsive forms for selective delivery of therapeutic drugs to the tumour site has been extended to improve efficacy and reduce the severe side effects. Recent advances in nanotechnology offer promising breakthroughs in the diagnosis, treatment and monitoring of cancer cells. In this review, the specific design of DDSs based on the different nano-particles and their surface engineering is discussed. In addition, the innovative clinical studies in which nano-based DDS was used in the treatment of HCC were highlighted.
摘要：
肝细胞癌（HCC）的高复发率和药物治疗后的不良预后反映了改进当前化疗方案的必要性。特别是药物输送方法。开发靶向和有效的药物递送系统，在所有活动中，被动,和用于将治疗药物选择性递送到肿瘤部位的刺激响应形式已经被扩展以提高功效并减少严重的副作用。纳米技术的最新进展为诊断提供了有希望的突破，治疗,和监测癌细胞。在这次审查中,讨论了基于不同纳米颗粒的药物递送系统（DDS）的具体设计及其表面工程。此外,强调了基于纳米DDS治疗HCC的创新性临床研究。
