PDF(Pubmed)
Abstract：
Breast cancer, a prominent cause of mortality among women, develops from abnormal growth of breast tissue, thereby rendering it one of the most commonly detected cancers in the female population. Although numerous treatment strategies are available for breast cancer, discordance in terms of effective treatment and response still exists. Recently, the potential of signaling pathways and transcription factors has gained substantial attention in the cancer community; therefore, understanding their role will assist researchers in comprehending the onset and advancement of breast cancer. Forkhead box (FOX) proteins, which are important transcription factors, are considered crucial regulators of various cellular activities, including cell division and proliferation. The present study explored several subclasses of FOX proteins and their possible role in breast carcinogenesis, followed by the interaction between microRNA (miRNA) and FOX proteins. This interaction is implicated in promoting cell infiltration into surrounding tissues, ultimately leading to metastasis. The various roles that FOX proteins play in breast cancer development, their intricate relationships with miRNA, and their involvement in therapeutic resistance highlight the complexity of breast cancer dynamics. Therefore, recognizing the progress and challenges in current treatments is crucial because, despite advancements, persistent disparities in treatment effectiveness underscore the need for ongoing research, with future studies emphasizing the necessity for targeted strategies that account for the multifaceted aspects of breast cancer.
摘要：
乳腺癌,女性死亡的主要原因，从乳房组织的异常生长发展，从而使其成为女性人群中最常见的癌症之一。尽管乳腺癌有许多治疗策略，在有效治疗和反应方面仍然存在不一致。最近,信号通路和转录因子的潜力已在癌症界获得了极大的关注;因此,了解它们的作用将有助于研究人员理解乳腺癌的发病和进展。叉头盒（FOX）蛋白，它们是重要的转录因子，被认为是各种细胞活动的关键调节剂，包括细胞分裂和增殖。本研究探讨了FOX蛋白的几个亚类及其在乳腺癌发生中的可能作用。其次是microRNA（miRNA）和FOX蛋白之间的相互作用。这种相互作用与促进细胞浸润到周围组织有关，最终导致转移。FOX蛋白在乳腺癌发展中所起的各种作用,它们与miRNA的复杂关系，它们参与治疗抗性突出了乳腺癌动力学的复杂性。因此,认识到当前治疗的进展和挑战至关重要，因为，尽管取得了进步，治疗效果的持续差异强调了持续研究的必要性，未来的研究强调有针对性的策略，以解决乳腺癌的多方面问题。
