PDF(Pubmed)
Abstract：
Several studies have indicated that the gut microbiome and tumor microbiota may affect tumors. Emerging metabolomics research illustrates the need to examine the variations in microbial metabolite composition between patients with cancer and healthy individuals. Microbial metabolites can impact the progression of tumors and the immune response by influencing a number of mechanisms, including modulation of the immune system, cancer or immune‑related signaling pathways, epigenetic modification of proteins and DNA damage. Microbial metabolites can also alleviate side effects and drug resistance during chemotherapy and immunotherapy, while effectively activating the immune system to exert tumor immunotherapy. Nevertheless, the impact of microbial metabolites on tumor immunity can be both beneficial and harmful, potentially influenced by the concentration of the metabolites or the specific cancer type. The present review summarizes the roles of various microbial metabolites in different solid tumors, alongside their influence on tumor immunity and treatment. Additionally, clinical trials evaluating the therapeutic effects of microbial metabolites or related microbes on patients with cancer have been listed. In summary, studying microbial metabolites, which play a crucial role in the interaction between the microbiota and tumors, could lead to the identification of new supplementary treatments for cancer. This has the potential to improve the effectiveness of cancer treatment and enhance patient prognosis.
摘要：
多项研究表明，肠道微生物组和肿瘤微生物群可能会影响肿瘤。新兴的代谢组学研究表明，需要检查癌症患者和健康个体之间的微生物代谢物组成变化。微生物代谢产物可以通过影响多种机制影响肿瘤的进展和免疫反应。包括免疫系统的调节，癌症或免疫相关信号通路，蛋白质的表观遗传修饰和DNA损伤。微生物代谢产物还可以减轻化疗和免疫治疗过程中的副作用和耐药性，同时有效激活免疫系统发挥肿瘤免疫治疗作用。然而，微生物代谢产物对肿瘤免疫的影响既有益又有害,可能受代谢物浓度或特定癌症类型的影响。本文综述了各种微生物代谢产物在不同实体瘤中的作用。以及它们对肿瘤免疫和治疗的影响。此外,已经列出了评估微生物代谢物或相关微生物对癌症患者治疗效果的临床试验。总之,研究微生物代谢物，在微生物群和肿瘤之间的相互作用中起着至关重要的作用，可能导致识别新的癌症辅助治疗方法。这有可能提高癌症治疗的有效性并增强患者预后。
