关键词: adrenal insufficiency corticotherapy corticotropic insufficiency pregnancy

来  源:   DOI:10.1097/MS9.0000000000002084   PDF(Pubmed)

Abstract:
UNASSIGNED: Adrenal insufficiency is a rare chronic disease with a prevalence of 39 to 60 cases per million peoples in Europe. However, the prevalence is higher in sub-saharian Africa. The occurrence of pregnancy in adrenal insufficiency is rare but associated with high maternal and perinatal morbidity and mortality. For this reason, the management of pregnancy in adrenal insufficiency patient must be provided by a multidisciplinary team.
UNASSIGNED: The authors report the case of a 34-year-old pregnant woman followed for adrenal insufficiency secondary to prolonged corticosteroid therapy. Treatment consisted to an obstetrical and endocrinological follow-up and corticosteroid replacement therapy with hydrocortisone. A prophylactic cesarean section at 38 weeks resulted in the birth of a newborn male weighing 3395 g. Maternal and perinatal prognosis was good.
UNASSIGNED: Pregnancy in adrenal insufficiency is a therepeutic challenge in developing countries. Through this case, the authors discuss the therapeutic and prognostic aspects of adrenal insufficiency in our setting.
UNASSIGNED: With the introduction of gluco-corticosteroid replacement therapy, pregnancy in adrenal insufficiency can progress normally.
摘要:
肾上腺功能不全是一种罕见的慢性疾病,在欧洲每百万人中有39至60例。然而,撒哈拉以南非洲的患病率较高.肾上腺功能不全的妊娠很少发生,但与高孕产妇和围产期发病率和死亡率有关。出于这个原因,肾上腺功能不全患者的妊娠管理必须由多学科小组提供.
作者报告了一例34岁的孕妇因长期皮质类固醇治疗继发的肾上腺功能不全。治疗包括产科和内分泌随访以及氢化可的松的皮质类固醇替代疗法。在38周时进行预防性剖宫产导致出生了一名体重为3395g的新生儿男性。孕产妇和围产期预后良好。
肾上腺功能不全的妊娠在发展中国家是一个严重的挑战。通过这个案子,作者讨论了肾上腺功能不全的治疗和预后方面。
随着糖皮质激素替代疗法的引入,妊娠中肾上腺功能不全可正常进展。
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