PDF(Pubmed)
Abstract：
UNASSIGNED: Spinal anesthesia is commonly performed for cesarean section, however, postdural puncture headache (PDPH) is one of its most common adverse effects. Ondansetron is an antiemetic for cancer treatment and analgesia-induced nausea and vomiting. In this study, the authors aim to evaluate the effect of postoperative ondansetron on PDPH.
UNASSIGNED: In this randomized controlled clinical trial study, 120 pregnant patients are ASA ll, undergoing elective cesarean section, were randomized into two groups (placebo or study). The patients in the study group, immediately after the birth of a baby and 24 h after the operation, received ondansetron 4 mg IV while the placebo group received a placebo. The severity and incidence of headache, postoperative nausea and vomiting, dizziness, neck and lower back pain, and the use of analgesia was assessed in the two groups.
UNASSIGNED: The significant meaning of the time effect (P<0.001) indicated that regardless of the group, for each unit increase in time, the chance of developing a headache increased by 23%, which was statistically significant. Also, the significant meaning of the group effect indicated that regardless of time, patients who did not take indomethacin had ~4.11 times higher chances of developing a headache compared to those who received the medication, which was statistically significant (P=0.004).
UNASSIGNED: The administration of ondansetron significantly reduces the occurrence of postspinal anesthesia headaches and neck pain. There was no significant difference in headache severity between the two study groups.
UNASSIGNED: In this randomized controlled clinical trial study, 120 pregnant patients are ASA ll, undergoing elective cesarean section, were randomized into two groups (placebo or study). The patients in the study group, immediately after the birth of a baby and 24 h after the operation, received ondansetron 4 mg IV while the placebo group received a placebo. The severity and incidence of headache, postoperative nausea and vomiting, dizziness, neck and lower back pain, and the use of analgesia was assessed in the two groups.
UNASSIGNED: The significant meaning of the time effect (P<0.001) indicated that regardless of the group, for each unit increase in time, the chance of developing a headache increased by 23%, which was statistically significant. Also, the significant meaning of the group effect indicated that regardless of time, patients who did not take indomethacin had ~4.11 times higher chances of developing a headache compared to those who received the medication, which was statistically significant (P=0.004).
UNASSIGNED: The administration of ondansetron significantly reduces the occurrence of postspinal anesthesia headaches and neck pain. There was no significant difference in headache severity between the two study groups.
摘要：
■脊柱麻醉通常用于剖宫产，然而,硬膜穿刺头痛(PDPH)是其最常见的不良反应之一。昂丹司琼是一种止吐药，用于癌症治疗和镇痛引起的恶心和呕吐。在这项研究中,作者旨在评估术后昂丹司琼对PDPH的影响。
■在这项随机对照临床试验研究中，120名怀孕患者是ASAII，进行选择性剖宫产,随机分为两组（安慰剂或研究）。研究组患者,婴儿出生后和手术后24小时，接受昂丹司琼4mg静脉注射治疗,而安慰剂组接受安慰剂治疗.头痛的严重程度和发生率，术后恶心呕吐,头晕,颈部和下背部疼痛，并对两组的镇痛使用情况进行评估。
■时间效应的显着意义（P<0.001）表明，无论哪个组，每增加一个单位的时间，患头痛的几率增加了23%,具有统计学意义。此外，群体效应的显著意义表明，无论时间长短，与接受药物治疗的患者相比，未服用消炎痛的患者发生头痛的几率约为4.11倍，有统计学意义(P=0.004)。
■服用昂丹司琼可显着减少脊髓麻醉后头痛和颈部疼痛的发生。两个研究组之间的头痛严重程度没有显着差异。
■在这项随机对照临床试验研究中，120名怀孕患者是ASAII，进行选择性剖宫产,随机分为两组（安慰剂或研究）。研究组患者,婴儿出生后和手术后24小时，接受昂丹司琼4mg静脉注射治疗,而安慰剂组接受安慰剂治疗.头痛的严重程度和发生率，术后恶心呕吐,头晕,颈部和下背部疼痛，并对两组的镇痛使用情况进行评估。
■时间效应的显着意义（P<0.001）表明，无论哪个组，每增加一个单位的时间，患头痛的几率增加了23%,具有统计学意义。此外，群体效应的显著意义表明，无论时间长短，与接受药物治疗的患者相比，未服用消炎痛的患者发生头痛的几率约为4.11倍，有统计学意义(P=0.004)。
■服用昂丹司琼可显着减少脊髓麻醉后头痛和颈部疼痛的发生。两个研究组之间的头痛严重程度没有显着差异。
