UNASSIGNED: We adopted a retrospective case-control modality for this investigation. An aggregate of 39 HSIL patients and 42 cervical carcinoma patients, who were treated in our facility from July 2020 to September 2023, were meticulously selected. Each case of cervical malignancy was confirmed through rigorous histopathological scrutiny. Concomitantly, 31 healthy female individuals, who underwent prophylactic health evaluations during the corresponding timeframe, were enlisted as the baseline control group. We systematically gathered and analyzed clinical demographics, as well as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), from peripheral blood samples. Pearson\'s correlation coefficient was deployed to dissect the interrelation between peripheral NLR and PLR concentrations and the clinicopathological features in the cervical cancer group.
UNASSIGNED: Inter-group comparative analysis unveiled statistically substantial variances in the PLR and NLR values among the tripartite clusters (F = 36.941, 14.998, P < 0.001, respectively). Although discrepancy in NLR (P = 0.061) and PLR (P = 0.759) measures between the groups of cervical carcinoma and HSIL was not statistically appreciable, these indices were markedly elevated in the cervical carcinoma faction as juxtaposed with the normative control group (t = 5.094, 5.927; P < 0.001 for both parameters). A discernible gradation in peripheral blood PLR and NLR concentrations was noted when stratified by clinical stage and the profundity of myometrial invasion in cervical cancer subjects (P < 0.001). The correlation matrix demonstrated a positive liaison between peripheral blood PLR and the clinical gradation, as well as the invasiveness of the neoplastic cells into the muscularis propria (P < 0.05); a similar trend was observed with the NLR values (P < 0.05).
UNASSIGNED: Augmented NLR and PLR levels in peripheral blood specimens are indicative of HSIL and cervical malignancy. These hematological parameters exhibit a pronounced interconnection with clinical staging and muscular wall penetration depth, serving as potential discriminative biomarkers for the diagnosis and prognosis of cervical cancer.
■本研究采用回顾性病例对照模式。总计39例HSIL患者和42例宫颈癌患者,从2020年7月至2023年9月在我们的设施中接受治疗的人是经过精心挑选的。通过严格的组织病理学检查确认了每例宫颈恶性肿瘤。同时,31个健康的女性个体,他们在相应的时间范围内接受了预防性健康评估,被列为基线对照组。我们系统地收集和分析了临床人口统计学,以及中性粒细胞与淋巴细胞比率(NLR)和血小板与淋巴细胞比率(PLR),来自外周血样本。采用Pearson相关系数分析宫颈癌组外周NLR和PLR浓度与临床病理特征之间的相互关系。
■组间比较分析揭示了三方簇之间PLR和NLR值的统计学实质性差异(分别为F=36.941,14.998,P<0.001)。尽管宫颈癌组和HSIL组之间的NLR(P=0.061)和PLR(P=0.759)测量值差异无统计学意义,与普通对照组并列的宫颈癌组,这些指标显着升高(t=5.094,5.927;两个参数均P<0.001)。当按临床分期和宫颈癌受试者的子宫肌层浸润深度分层时,发现外周血PLR和NLR浓度的可辨别的分级(P<0.001)。相关矩阵显示外周血PLR与临床分级之间的正联系,以及肿瘤细胞对固有肌层的侵袭性(P<0.05);NLR值观察到类似的趋势(P<0.05)。
■外周血标本中增加的NLR和PLR水平指示HSIL和宫颈恶性肿瘤。这些血液学参数与临床分期和肌壁穿透深度表现出明显的相互联系,作为宫颈癌诊断和预后的潜在鉴别性生物标志物。