PDF(Pubmed)
Abstract：
UNASSIGNED: Fibromyalgia (FM) has been associated with decreased hippocampal volume; however, the atrophy patterns of hippocampal subregions have not yet been identified. We therefore aimed to evaluate the volumes of hippocampal subregions in FM patients with mild cognitive impairment (MCI), and to explore the relationship between different subregional alterations and cognitive function.
UNASSIGNED: The study included 35 FM patients (21 with MCI and 14 without MCI) and 35 healthy subjects. All subjects performed the Montreal Cognitive Assessment (MoCA) to assess cognitive function. FreeSurfer V.7.3.2 was used to calculate hippocampal subregion volumes. We then compared hippocampal subregion volumes between the groups, and analyzed the relationship between hippocampal subregion volume and cognitive function using a partial correlation analysis method.
UNASSIGNED: Compared with the healthy subjects, FM patients with MCI had smaller hippocampal volumes in the left and right CA1 head, Molecular layer head, GC-DG head, and CA4 head, and in the left Presubiculum head. Poorer executive function, naming ability, and attention were associated with left CA1 head and left Molecular layer head atrophy. By contrast, hippocampal subregion volumes in the FM patients without MCI were slightly larger than or similar to those in the healthy subjects, and were not significantly correlated with cognitive function.
UNASSIGNED: Smaller volumes of left CA1 head and left Molecular layer head were associated with poorer executive function, naming ability, and attention in FM patients with MCI. However, these results were not observed in the FM patients without MCI. These findings suggest that the hippocampal subregions of FM patients might present compensatory mechanisms before cognitive decline occurs.
UNASSIGNED: The study included 35 FM patients (21 with MCI and 14 without MCI) and 35 healthy subjects. All subjects performed the Montreal Cognitive Assessment (MoCA) to assess cognitive function. FreeSurfer V.7.3.2 was used to calculate hippocampal subregion volumes. We then compared hippocampal subregion volumes between the groups, and analyzed the relationship between hippocampal subregion volume and cognitive function using a partial correlation analysis method.
UNASSIGNED: Compared with the healthy subjects, FM patients with MCI had smaller hippocampal volumes in the left and right CA1 head, Molecular layer head, GC-DG head, and CA4 head, and in the left Presubiculum head. Poorer executive function, naming ability, and attention were associated with left CA1 head and left Molecular layer head atrophy. By contrast, hippocampal subregion volumes in the FM patients without MCI were slightly larger than or similar to those in the healthy subjects, and were not significantly correlated with cognitive function.
UNASSIGNED: Smaller volumes of left CA1 head and left Molecular layer head were associated with poorer executive function, naming ability, and attention in FM patients with MCI. However, these results were not observed in the FM patients without MCI. These findings suggest that the hippocampal subregions of FM patients might present compensatory mechanisms before cognitive decline occurs.
摘要：
■纤维肌痛（FM）与海马体积减少有关；然而，海马亚区的萎缩模式尚未确定。因此，我们旨在评估轻度认知障碍（MCI）的FM患者海马亚区的体积，并探讨不同次区域改变与认知功能的关系。
■该研究包括35名FM患者（21名MCI患者和14名无MCI患者）和35名健康受试者。所有受试者进行蒙特利尔认知评估(MoCA)以评估认知功能。FreeSurferV.7.3.2用于计算海马子区域体积。然后我们比较了各组之间的海马子区域体积，用偏相关分析方法分析海马亚区体积与认知功能的关系。
■与健康受试者相比，MCI的FM患者在左、右CA1头有较小的海马体积,分子层头,GC-DG头,和CA4头，在左前下颌头。执行功能较差，命名能力，注意力与左侧CA1头和左侧分子层头部萎缩有关。相比之下,没有MCI的FM患者的海马子区域体积比健康受试者略大或相似，与认知功能无显著相关性。
■左侧CA1头和左侧分子层头的体积较小与执行功能较差有关，命名能力，MCI的FM患者的注意力。然而,在没有MCI的FM患者中未观察到这些结果.这些发现表明，FM患者的海马亚区可能在认知功能下降发生之前就存在代偿机制。
■该研究包括35名FM患者（21名MCI患者和14名无MCI患者）和35名健康受试者。所有受试者进行蒙特利尔认知评估(MoCA)以评估认知功能。FreeSurferV.7.3.2用于计算海马子区域体积。然后我们比较了各组之间的海马子区域体积，用偏相关分析方法分析海马亚区体积与认知功能的关系。
■与健康受试者相比，MCI的FM患者在左、右CA1头有较小的海马体积,分子层头,GC-DG头,和CA4头，在左前下颌头。执行功能较差，命名能力，注意力与左侧CA1头和左侧分子层头部萎缩有关。相比之下,没有MCI的FM患者的海马子区域体积比健康受试者略大或相似，与认知功能无显著相关性。
■左侧CA1头和左侧分子层头的体积较小与执行功能较差有关，命名能力，MCI的FM患者的注意力。然而,在没有MCI的FM患者中未观察到这些结果.这些发现表明，FM患者的海马亚区可能在认知功能下降发生之前就存在代偿机制。
