PDF(Pubmed)
Abstract：
UNASSIGNED: Intraocular malignant tumors represent a severe disease that threatens vision as well as life. To better extend the life of the patient, preserve visual function, and maintain ocular aesthetics, selecting the appropriate timing and methods of treatment becomes crucial.
UNASSIGNED: With the continuous advancement of medical technology, the techniques and methods for treating intraocular malignant tumors are constantly evolving. While surgery was once considered the optimal method to prolong patient survival and prevent local recurrence, the discovery and application of various treatments such as radiotherapy, laser therapy, chemotherapy, cryotherapy, and monoclonal antibodies have led to a greater diversity of treatment options. This diversity offers more possibilities to develop personalized treatment plans, and thereby maximize patient benefit. This article reviews the various treatment methods for intraocular malignant tumors, including indications for treatment, outcomes, and potential complications.
UNASSIGNED: Differentiating small intraocular malignant tumors from pigmented lesions is challenging, and ongoing monitoring with regular follow-up is required. Small to medium-sized tumors can be treated with radiotherapy combined with transpupillary thermotherapy. Depending on the tumor\'s distance from the optic disc, surgery with partial resection may be considered for distant tumors, while proximal tumors may require complete enucleation. Systemic chemotherapy has been widely applied to patients with retinal tumors, lymphomas, and intraocular metastatic cancers, but has limited efficacy in patients with choroidal melanoma. Antagonists of Vascular Endothelial Growth Factor (Anti-VEGF) drugs can improve patient vision and quality of life, while the efficacy of immunotherapy and molecular targeted therapy is still under research.
UNASSIGNED: With the continuous advancement of medical technology, the techniques and methods for treating intraocular malignant tumors are constantly evolving. While surgery was once considered the optimal method to prolong patient survival and prevent local recurrence, the discovery and application of various treatments such as radiotherapy, laser therapy, chemotherapy, cryotherapy, and monoclonal antibodies have led to a greater diversity of treatment options. This diversity offers more possibilities to develop personalized treatment plans, and thereby maximize patient benefit. This article reviews the various treatment methods for intraocular malignant tumors, including indications for treatment, outcomes, and potential complications.
UNASSIGNED: Differentiating small intraocular malignant tumors from pigmented lesions is challenging, and ongoing monitoring with regular follow-up is required. Small to medium-sized tumors can be treated with radiotherapy combined with transpupillary thermotherapy. Depending on the tumor\'s distance from the optic disc, surgery with partial resection may be considered for distant tumors, while proximal tumors may require complete enucleation. Systemic chemotherapy has been widely applied to patients with retinal tumors, lymphomas, and intraocular metastatic cancers, but has limited efficacy in patients with choroidal melanoma. Antagonists of Vascular Endothelial Growth Factor (Anti-VEGF) drugs can improve patient vision and quality of life, while the efficacy of immunotherapy and molecular targeted therapy is still under research.
摘要：
■眼内恶性肿瘤是一种威胁视力和生命的严重疾病。为了更好地延长病人的寿命，保持视觉功能，保持眼部美学，选择合适的治疗时机和方法变得至关重要。
■随着医疗技术的不断进步,治疗眼内恶性肿瘤的技术和方法不断发展。虽然手术曾经被认为是延长患者生存期和防止局部复发的最佳方法，放射治疗等各种治疗方法的发现和应用，激光治疗,化疗,冷冻疗法,和单克隆抗体导致了更多的治疗选择。这种多样性为制定个性化治疗计划提供了更多可能性，从而最大限度地提高患者的利益。本文综述了眼内恶性肿瘤的各种治疗方法,包括治疗适应症，结果，和潜在的并发症。
■区分眼内小型恶性肿瘤和色素性病变具有挑战性，需要持续监测和定期随访。中小型肿瘤可采用放疗联合经瞳孔热疗治疗。根据肿瘤离视盘的距离,对于远处肿瘤，可以考虑进行部分切除手术，而近端肿瘤可能需要完全摘除。全身化疗已广泛应用于视网膜肿瘤患者,淋巴瘤,和眼内转移性癌症，但对脉络膜黑色素瘤患者的疗效有限。血管内皮生长因子（抗VEGF）药物的拮抗剂可以改善患者的视力和生活质量，而免疫治疗和分子靶向治疗的疗效仍在研究中。
■随着医疗技术的不断进步,治疗眼内恶性肿瘤的技术和方法不断发展。虽然手术曾经被认为是延长患者生存期和防止局部复发的最佳方法，放射治疗等各种治疗方法的发现和应用，激光治疗,化疗,冷冻疗法,和单克隆抗体导致了更多的治疗选择。这种多样性为制定个性化治疗计划提供了更多可能性，从而最大限度地提高患者的利益。本文综述了眼内恶性肿瘤的各种治疗方法,包括治疗适应症，结果，和潜在的并发症。
■区分眼内小型恶性肿瘤和色素性病变具有挑战性，需要持续监测和定期随访。中小型肿瘤可采用放疗联合经瞳孔热疗治疗。根据肿瘤离视盘的距离,对于远处肿瘤，可以考虑进行部分切除手术，而近端肿瘤可能需要完全摘除。全身化疗已广泛应用于视网膜肿瘤患者,淋巴瘤,和眼内转移性癌症，但对脉络膜黑色素瘤患者的疗效有限。血管内皮生长因子（抗VEGF）药物的拮抗剂可以改善患者的视力和生活质量，而免疫治疗和分子靶向治疗的疗效仍在研究中。
