PDF(Pubmed)
Abstract：
UNASSIGNED: Currently, there is limited and inconsistent evidence regarding the risk association between daily dietary intake, antioxidants, minerals, and vitamins with Childhood Asthma (CA). Therefore, this study employs Mendelian Randomization (MR) methodology to systematically investigate the causal relationships between daily dietary intake, serum antioxidants, serum minerals, and the circulating levels of serum vitamins with CA.
UNASSIGNED: This study selected factors related to daily dietary intake, including carbohydrates, proteins, fats, and sugars, as well as serum antioxidant levels (lycopene, uric acid, and β-carotene), minerals (calcium, copper, selenium, zinc, iron, phosphorus, and magnesium), and vitamins (vitamin A, vitamin B6, folate, vitamin B12, vitamin C, vitamin D, and vitamin E), using them as Instrumental Variables (IVs). Genetic data related to CA were obtained from the FinnGen and GWAS Catalog databases, with the primary analytical methods being Inverse Variance Weighting (IVW) and sensitivity analysis.
UNASSIGNED: Following MR analysis, it is observed that sugar intake (OR: 0.71, 95% CI: 0.55-0.91, P: 0.01) is inversely correlated with the risk of CA, while the intake of serum circulating magnesium levels (OR: 1.63, 95% CI: 1.06-2.53, P: 0.03), fats (OR: 1.44, 95% CI: 1.06-1.95, P: 0.02), and serum vitamin D levels (OR: 1.14, 95% CI: 1.04-1.25, P: 0.02) are positively associated with an increased risk of CA.
UNASSIGNED: This study identified a causal relationship between the daily dietary intake of sugars and fats, as well as the magnesium and vitamin D levels in serum, and the occurrence of CA. However, further in-depth research is warranted to elucidate the specific mechanisms underlying these associations.
UNASSIGNED: This study selected factors related to daily dietary intake, including carbohydrates, proteins, fats, and sugars, as well as serum antioxidant levels (lycopene, uric acid, and β-carotene), minerals (calcium, copper, selenium, zinc, iron, phosphorus, and magnesium), and vitamins (vitamin A, vitamin B6, folate, vitamin B12, vitamin C, vitamin D, and vitamin E), using them as Instrumental Variables (IVs). Genetic data related to CA were obtained from the FinnGen and GWAS Catalog databases, with the primary analytical methods being Inverse Variance Weighting (IVW) and sensitivity analysis.
UNASSIGNED: Following MR analysis, it is observed that sugar intake (OR: 0.71, 95% CI: 0.55-0.91, P: 0.01) is inversely correlated with the risk of CA, while the intake of serum circulating magnesium levels (OR: 1.63, 95% CI: 1.06-2.53, P: 0.03), fats (OR: 1.44, 95% CI: 1.06-1.95, P: 0.02), and serum vitamin D levels (OR: 1.14, 95% CI: 1.04-1.25, P: 0.02) are positively associated with an increased risk of CA.
UNASSIGNED: This study identified a causal relationship between the daily dietary intake of sugars and fats, as well as the magnesium and vitamin D levels in serum, and the occurrence of CA. However, further in-depth research is warranted to elucidate the specific mechanisms underlying these associations.
摘要：
■目前，关于每日饮食摄入量之间的风险关联的证据有限且不一致，抗氧化剂,矿物,和维生素与儿童哮喘（CA）。因此,这项研究采用孟德尔随机化（MR）方法来系统地研究每日饮食摄入量之间的因果关系，血清抗氧化剂，血清矿物质，和CA血清维生素的循环水平。
■这项研究选择了与每日饮食摄入量相关的因素，包括碳水化合物,蛋白质，脂肪，和糖，以及血清抗氧化剂水平(番茄红素，尿酸,和β-胡萝卜素），矿物质(钙，铜，硒,锌，铁,磷，和镁），和维生素（维生素A，维生素B6，叶酸，维生素B12，维生素C，维生素D,和维生素E），使用它们作为工具变量(IV)。与CA相关的遗传数据来自FinnGen和GWAS目录数据库，主要的分析方法是方差反加权(IVW)和灵敏度分析。
■MR分析后，观察到糖摄入量（OR：0.71，95％CI：0.55-0.91，P：0.01）与CA的风险呈负相关，而摄入的血清循环镁水平(OR:1.63,95%CI:1.06-2.53,P:0.03),脂肪（OR：1.44，95%CI：1.06-1.95，P：0.02），血清维生素D水平（OR：1.14，95％CI：1.04-1.25，P：0.02）与CA风险增加呈正相关。
■这项研究确定了每日饮食中糖和脂肪摄入量之间的因果关系，以及血清中的镁和维生素D水平，以及CA的发生。然而,需要进一步深入研究,以阐明这些关联背后的具体机制.
■这项研究选择了与每日饮食摄入量相关的因素，包括碳水化合物,蛋白质，脂肪，和糖，以及血清抗氧化剂水平(番茄红素，尿酸,和β-胡萝卜素），矿物质(钙，铜，硒,锌，铁,磷，和镁），和维生素（维生素A，维生素B6，叶酸，维生素B12，维生素C，维生素D,和维生素E），使用它们作为工具变量(IV)。与CA相关的遗传数据来自FinnGen和GWAS目录数据库，主要的分析方法是方差反加权(IVW)和灵敏度分析。
■MR分析后，观察到糖摄入量（OR：0.71，95％CI：0.55-0.91，P：0.01）与CA的风险呈负相关，而摄入的血清循环镁水平(OR:1.63,95%CI:1.06-2.53,P:0.03),脂肪（OR：1.44，95%CI：1.06-1.95，P：0.02），血清维生素D水平（OR：1.14，95％CI：1.04-1.25，P：0.02）与CA风险增加呈正相关。
■这项研究确定了每日饮食中糖和脂肪摄入量之间的因果关系，以及血清中的镁和维生素D水平，以及CA的发生。然而,需要进一步深入研究,以阐明这些关联背后的具体机制.
