PDF(Pubmed)
Abstract：
UNASSIGNED: To research the connection between the indexes of the indexes of triglyceride-glucose (TyG) combined with obesity indices and the initial neurological severity and short-term outcome of new-onset acute ischemic stroke.
UNASSIGNED: Data of patients with acute ischemic stroke admitted to the Stroke Ward of the Affiliated Hospital of Beihua University from November 2021 to October 2023, were collected. The two indexes were calculated by combining TyG and obesity indices: TyG-body mass index (TyG-BMI) and TyG-waist circumference (TyG-WC). The National Institute of Health Stroke Scale (NIHSS) was used to assess and group patients with neurological deficits within 24 hours of admission: mild stroke (NIHSS ≤5) and moderate-severe stroke (NIHSS >5). Short-term prognosis was evaluated using the modified Rankin Scale (mRS) at discharge or 14 days after onset of the disease and grouped: good outcome (mRS ≤2) and poor outcome (mRS >2). According to the quartiles of TyG-BMI and TyG-WC, the patients were placed into four groups: Q1, Q2, Q3 and Q4. Multi-factor logistic regression analysis was utilized to evaluate the correlation of TyG-BMI and TyG-WC with the severity and short-term outcome.
UNASSIGNED: The study included 456 patients. After adjusting for multiple variables, the results showed that compared with the quartile 1, patients in quartile 4 of TyG-BMI had a reduced risk of moderate-severe stroke [Q4: OR: 0.407, 95%CI (0.185-0.894), P = 0.025]; Patients in quartiles 2, 3 and 4 of TyG-BMI had sequentially lower risk of short-term adverse outcomes [Q2: OR: 0.394, 95%CI (0.215-0.722), P = 0.003; Q3: OR: 0.324, 95%CI (0.163-0.642), P = 0.001; Q4: OR: 0.158, 95%CI (0.027-0.349), P <0.001]; Patients in quartiles 3 and 4 of TyG-WC had sequentially lower risk of moderate-severe stroke [Q3: OR: 0.355, 95%CI (0.173-0.728), P = 0.005; Q4: OR: 0.140, 95%CI (0.056-0.351), P <0.001]; Patients in quartiles 3 and 4 of TyG-WC had sequentially lower risk of short-term adverse outcomes [Q3: OR: 0.350, 95%CI (0.175-0.700), P = 0.003; Q4: OR: 0.178, 95%CI (0.071-0.451), P <0.001].
UNASSIGNED: TyG-WC and TyG-BMI were correlated with the severity and short-term outcome of new-onset acute ischemic stroke. As TyG-WC and TyG-BMI increased, stroke severity decreased and short-term outcome was better.
UNASSIGNED: Data of patients with acute ischemic stroke admitted to the Stroke Ward of the Affiliated Hospital of Beihua University from November 2021 to October 2023, were collected. The two indexes were calculated by combining TyG and obesity indices: TyG-body mass index (TyG-BMI) and TyG-waist circumference (TyG-WC). The National Institute of Health Stroke Scale (NIHSS) was used to assess and group patients with neurological deficits within 24 hours of admission: mild stroke (NIHSS ≤5) and moderate-severe stroke (NIHSS >5). Short-term prognosis was evaluated using the modified Rankin Scale (mRS) at discharge or 14 days after onset of the disease and grouped: good outcome (mRS ≤2) and poor outcome (mRS >2). According to the quartiles of TyG-BMI and TyG-WC, the patients were placed into four groups: Q1, Q2, Q3 and Q4. Multi-factor logistic regression analysis was utilized to evaluate the correlation of TyG-BMI and TyG-WC with the severity and short-term outcome.
UNASSIGNED: The study included 456 patients. After adjusting for multiple variables, the results showed that compared with the quartile 1, patients in quartile 4 of TyG-BMI had a reduced risk of moderate-severe stroke [Q4: OR: 0.407, 95%CI (0.185-0.894), P = 0.025]; Patients in quartiles 2, 3 and 4 of TyG-BMI had sequentially lower risk of short-term adverse outcomes [Q2: OR: 0.394, 95%CI (0.215-0.722), P = 0.003; Q3: OR: 0.324, 95%CI (0.163-0.642), P = 0.001; Q4: OR: 0.158, 95%CI (0.027-0.349), P <0.001]; Patients in quartiles 3 and 4 of TyG-WC had sequentially lower risk of moderate-severe stroke [Q3: OR: 0.355, 95%CI (0.173-0.728), P = 0.005; Q4: OR: 0.140, 95%CI (0.056-0.351), P <0.001]; Patients in quartiles 3 and 4 of TyG-WC had sequentially lower risk of short-term adverse outcomes [Q3: OR: 0.350, 95%CI (0.175-0.700), P = 0.003; Q4: OR: 0.178, 95%CI (0.071-0.451), P <0.001].
UNASSIGNED: TyG-WC and TyG-BMI were correlated with the severity and short-term outcome of new-onset acute ischemic stroke. As TyG-WC and TyG-BMI increased, stroke severity decreased and short-term outcome was better.
摘要：
■研究甘油三酯-葡萄糖(TyG)指标与肥胖指标的关系与新发急性缺血性卒中的初始神经严重程度和短期预后。
■收集2021年11月至2023年10月北华大学附属医院卒中病房收治的急性缺血性卒中患者的数据。通过结合TyG和肥胖指数计算这两个指标：TyG体重指数（TyG-BMI）和TyG腰围（TyG-WC）。采用美国国立卫生研究院卒中量表(NIHSS)对入院24小时内出现神经功能缺损的患者进行评估和分组：轻度卒中(NIHSS≤5)和中重度卒中(NIHSS>5)。在出院时或疾病发作后14天使用改良的Rankin量表（mRS）评估短期预后，并将其分组：预后良好（mRS≤2）和预后不良（mRS>2）。根据TyG-BMI和TyG-WC的四分位数，将患者分为4组:Q1,Q2,Q3和Q4.采用多因素logistic回归分析评估TyG-BMI和TyG-WC与严重程度和短期预后的相关性。
■该研究包括456名患者。调整多个变量后，结果显示，与四分位数1相比，TyG-BMI四分位数4的患者发生中重度中风的风险降低[Q4：OR：0.407，95CI（0.185-0.894），P=0.025]；TyG-BMI四分位数2、3和4的患者短期不良结局的风险依次较低[Q2：OR：0.394，95CI（0.215-0.722），P=0.003；Q3：OR：0.324，95CI（0.163-0.642），P=0.001；Q4：OR：0.158，95CI（0.027-0.349），P<0.001]；TyG-WC四分位数3和4的患者发生中重度卒中的风险依次较低[Q3：OR：0.355，95CI（0.173-0.728），P=0.005；Q4：OR：0.140，95CI（0.056-0.351），P<0.001]；TyG-WC四分位数3和4的患者短期不良结局的风险依次较低[Q3：OR：0.350，95CI（0.175-0.700），P=0.003；Q4：OR：0.178，95CI（0.071-0.451），P<0.001]。
■TyG-WC和TyG-BMI与新发急性缺血性卒中的严重程度和短期预后相关。随着TyG-WC和TyG-BMI的增加，卒中严重程度降低,短期结局更好.
■收集2021年11月至2023年10月北华大学附属医院卒中病房收治的急性缺血性卒中患者的数据。通过结合TyG和肥胖指数计算这两个指标：TyG体重指数（TyG-BMI）和TyG腰围（TyG-WC）。采用美国国立卫生研究院卒中量表(NIHSS)对入院24小时内出现神经功能缺损的患者进行评估和分组：轻度卒中(NIHSS≤5)和中重度卒中(NIHSS>5)。在出院时或疾病发作后14天使用改良的Rankin量表（mRS）评估短期预后，并将其分组：预后良好（mRS≤2）和预后不良（mRS>2）。根据TyG-BMI和TyG-WC的四分位数，将患者分为4组:Q1,Q2,Q3和Q4.采用多因素logistic回归分析评估TyG-BMI和TyG-WC与严重程度和短期预后的相关性。
■该研究包括456名患者。调整多个变量后，结果显示，与四分位数1相比，TyG-BMI四分位数4的患者发生中重度中风的风险降低[Q4：OR：0.407，95CI（0.185-0.894），P=0.025]；TyG-BMI四分位数2、3和4的患者短期不良结局的风险依次较低[Q2：OR：0.394，95CI（0.215-0.722），P=0.003；Q3：OR：0.324，95CI（0.163-0.642），P=0.001；Q4：OR：0.158，95CI（0.027-0.349），P<0.001]；TyG-WC四分位数3和4的患者发生中重度卒中的风险依次较低[Q3：OR：0.355，95CI（0.173-0.728），P=0.005；Q4：OR：0.140，95CI（0.056-0.351），P<0.001]；TyG-WC四分位数3和4的患者短期不良结局的风险依次较低[Q3：OR：0.350，95CI（0.175-0.700），P=0.003；Q4：OR：0.178，95CI（0.071-0.451），P<0.001]。
■TyG-WC和TyG-BMI与新发急性缺血性卒中的严重程度和短期预后相关。随着TyG-WC和TyG-BMI的增加，卒中严重程度降低,短期结局更好.
