PDF(Pubmed)
Abstract：
The case study aims to describe the nephrotic syndrome (NS) in a castrated 3-year-old male Cocker Spaniel dog. The patient arrived at the hospital with a loss of appetite and weakness. Skin oedema with ascites was observed along with hypoalbuminaemia, hypoproteinaemia, hyperlipidaemia, hypercholesterolaemia, and proteinuria (urine protein to creatinine ratio = 22.4). Based on these findings, the patient was diagnosed with NS, although a renal biopsy was not conducted. Prednisolone (1 mg/kg, p.o. q12 h) and mycophenolate mofetil (10 mg/kg, p.o. q12 h) were prescribed as the immunosuppressive drugs, and previously cryopreserved allogeneic adipose tissue-derived mesenchymal stem cells (2 × 107 cells/kg) were injected intravenously. After several weeks of treatment, the patient recovered from NS. This is the first case report on immunosuppressive drugs and allogeneic mesenchymal stem cells being used to treat a dog with NS.
摘要：
该案例研究旨在描述cast割的3岁雄性可卡猎犬的肾病综合征（NS）。病人到医院时食欲不振，身体虚弱。观察到皮肤水肿伴腹水并伴有低白蛋白血症，低蛋白血症,高脂血症,高胆固醇血症,和蛋白尿（尿蛋白与肌酐之比=22.4）。基于这些发现,患者被诊断为NS，尽管未进行肾活检。泼尼松龙（1mg/kg，p.o.q12h）和霉酚酸酯（10mg/kg，p.o.q12h)被规定为免疫抑制药物，和预先冷冻保存的同种异体脂肪组织间充质干细胞（2×107细胞/kg）静脉注射。经过几周的治疗，患者从NS中康复。这是关于免疫抑制药物和同种异体间充质干细胞用于治疗患有NS的狗的第一例报道。
