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Abstract：
Fibroblast growth factors (FGF) are a type of cell signaling proteins that are mostly produced by macrophages. They are essential for a variety of biological activities involved in normal development. Fibroblast growth factor 23 (FGF23) is the newest and youngest member of the FGF endocrine subfamily, along with fibroblast growth factor 19 (FGF19) and fibroblast growth factor 21 (FGF21). In this study, we conduct a systematic review of all known literature to identify the risk of elevated FGF23 in the cardiovascular system. The analysis includes the risk of cardiovascular disease for both primary and secondary causes of elevated FGF23, such as chronic renal insufficiency. This systematic literature review adhered to the Preferred Reporting Items and Meta-Analysis (PRISMA) standards. A total of 4,793 records were identified across different databases. After that, 273 records were retrieved and reviewed. After carefully examining the titles and summaries of each report, 249 additional entries were eliminated. About 24 studies from the remaining records were chosen by primary and secondary authors for screening, and they performed a quality assessment using common quality check tools. Finally, this review included 11 studies. Following a thorough analysis, we came to the conclusion that FGF23 can be regarded as a novel biomarker and should be included in the group of heart biomarkers that have already been identified, such as B-type natriuretic peptide (BNP), for the early identification of a variety of highly prevalent cardiovascular disorders.
摘要：
成纤维细胞生长因子(FGF)是一类主要由巨噬细胞产生的细胞信号蛋白。它们对于参与正常发育的各种生物活性是必不可少的。成纤维细胞生长因子23(FGF23)是FGF内分泌亚家族中最新、最年轻的成员。以及成纤维细胞生长因子19（FGF19）和成纤维细胞生长因子21（FGF21）。在这项研究中,我们对所有已知文献进行了系统回顾,以确定心血管系统中FGF23升高的风险.分析包括FGF23升高的主要和次要原因的心血管疾病风险，例如慢性肾功能不全。本系统文献综述遵循首选报告项目和荟萃分析(PRISMA)标准。在不同的数据库中总共识别了4,793条记录。之后,检索和审查了273条记录。在认真研究了每份报告的标题和摘要后,另外249个条目被删除。主要和次要作者从其余记录中选择了约24项研究进行筛查，他们使用常见的质量检查工具进行质量评估。最后,本综述包括11项研究.经过全面的分析，我们得出的结论是，FGF23可以被视为一种新的生物标志物，应该包括在已经确定的心脏生物标志物组中，如B型利钠肽（BNP），用于早期识别各种高度流行的心血管疾病。
