PDF(Pubmed)
Abstract：
Generalized pustular psoriasis of pregnancy (GPPP) is a rare dermatological condition that significantly affects maternal health and pregnancy outcomes. The treatment of this disease might be very challenging, as only a limited number of effective therapeutic options are available. If the use of systemic drugs is considered, they should ideally effectively control the systemic inflammation without harming the fetus. Here, we report the successful treatment of a severe case of GPPP in a 28-year-old woman using the tumor necrosis factor-alpha inhibitor (TNFi) certolizumab pegol. Additionally, we review the existing literature on the use of this class of drugs for treating GPPP. To date, there are only 11 reported cases of this severe skin condition treated with a TNFi. We also discuss the pathogenesis of GPPP and the rationale behind using TNFi for its treatment.
摘要：
妊娠合并脓疱型银屑病（GPPP）是一种罕见的皮肤病，显着影响孕产妇健康和妊娠结局。这种疾病的治疗可能非常具有挑战性，因为只有有限数量的有效治疗选择是可用的。如果考虑使用全身药物，理想情况下，它们应有效控制全身炎症而不伤害胎儿。这里,我们报道了1例28岁女性患者使用肿瘤坏死因子-α抑制剂(TNFi)赛托珠单抗pegol成功治疗GPPP的严重病例.此外,我们回顾了关于使用这类药物治疗GPPP的现有文献。迄今为止,只有11例报告的这种严重皮肤疾病用TNFi治疗.我们还讨论了GPPP的发病机制以及使用TNFi进行治疗的原理。
