PDF(Pubmed)
Abstract：
UNASSIGNED: The burden of advanced and metastatic cancer is high among children in developing countries, and palliative care (PC) services for children are sparsely available and poorly accessed. To estimate the burden of PC requirements in children with metastatic neuroblastoma (NB), and to evaluate the PC services offered.
UNASSIGNED: Retrospective analysis of case records of children 1-14 years diagnosed with metastatic NB from 1 January 2008 to 31 December 2017.
UNASSIGNED: One hundred and nineteen patients with metastatic NB were included, of which 87 patients received PC consultation. Early PC referral occurred only in 13 patients (14.9%), and pain was the most prominent symptom. Shifting of care from oncology to PC occurred at disease relapse in 58 patients (66.6%) and at end-of-life in 16 patients (18.3%). Nausea/vomiting, constipation and abdominal distension were the most common symptoms during end-of-life. Seventy-one patients (85%) died of disease, median time to death being 9 months from diagnosis and 4 months from relapse. The mean time from initiation of PC to death was 4.2 months.
UNASSIGNED: Timely integration of PC and shared care incorporating the oncology team, PC team and local paediatricians can ease out transition in care, ensure a continuum of care and improve the quality of treatment delivered to children with metastatic cancer.
UNASSIGNED: Retrospective analysis of case records of children 1-14 years diagnosed with metastatic NB from 1 January 2008 to 31 December 2017.
UNASSIGNED: One hundred and nineteen patients with metastatic NB were included, of which 87 patients received PC consultation. Early PC referral occurred only in 13 patients (14.9%), and pain was the most prominent symptom. Shifting of care from oncology to PC occurred at disease relapse in 58 patients (66.6%) and at end-of-life in 16 patients (18.3%). Nausea/vomiting, constipation and abdominal distension were the most common symptoms during end-of-life. Seventy-one patients (85%) died of disease, median time to death being 9 months from diagnosis and 4 months from relapse. The mean time from initiation of PC to death was 4.2 months.
UNASSIGNED: Timely integration of PC and shared care incorporating the oncology team, PC team and local paediatricians can ease out transition in care, ensure a continuum of care and improve the quality of treatment delivered to children with metastatic cancer.
摘要：
■发展中国家儿童的晚期和转移性癌症负担很高，为儿童提供的姑息治疗（PC）服务很少，而且难以获得。评估转移性神经母细胞瘤（NB）儿童的PC需求负担，并评估提供的PC服务。
■回顾性分析2008年1月1日至2017年12月31日诊断为转移性NB的1-14岁儿童病例记录。
■纳入了119例转移性NB患者，其中87名患者接受了PC咨询。早期PC转诊仅发生在13例患者中（14.9%），疼痛是最突出的症状。58名患者（66.6％）在疾病复发时和16名患者（18.3％）在生命结束时发生了从肿瘤学到PC的治疗转移。恶心/呕吐，便秘和腹胀是临终期最常见的症状.71例患者（85%）死于疾病，中位死亡时间为诊断后9个月,复发后4个月.从PC开始到死亡的平均时间为4.2个月。
■及时整合PC和肿瘤学团队的共享护理，PC团队和当地儿科医生可以缓解护理过渡，确保持续的护理，并提高为转移性癌症儿童提供的治疗质量。
■回顾性分析2008年1月1日至2017年12月31日诊断为转移性NB的1-14岁儿童病例记录。
■纳入了119例转移性NB患者，其中87名患者接受了PC咨询。早期PC转诊仅发生在13例患者中（14.9%），疼痛是最突出的症状。58名患者（66.6％）在疾病复发时和16名患者（18.3％）在生命结束时发生了从肿瘤学到PC的治疗转移。恶心/呕吐，便秘和腹胀是临终期最常见的症状.71例患者（85%）死于疾病，中位死亡时间为诊断后9个月,复发后4个月.从PC开始到死亡的平均时间为4.2个月。
■及时整合PC和肿瘤学团队的共享护理，PC团队和当地儿科医生可以缓解护理过渡，确保持续的护理，并提高为转移性癌症儿童提供的治疗质量。
