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Abstract：
Urinary tract infection (UTI) is a well-known bacterial infection posing serious health problem in children. A retrospective study was conducted to explore the uropathogen and its antibiotic resistance in children with UTI. Data of urine culture and antimicrobial susceptibility test was collected. Consequently, 840 children were included. The overall culture-positive UTI was 458 (54.52 %) with Escherichia coli 166 (36.24 %), followed by Enterococcus faecalis 59 (12.88 %), Enterococcus faecium 70 (15.28 %) and others. They were highly resistant to the most commonly used antibiotics. In 694 children with complicated UTI, there were 8 children with fungal infection. Multiple drug resistance (MDR) was recorded in 315 (80.98 %). The overall proportion of Extended Spectrum β-Lactamase (ESβL) production was 25 (6.43 %). In 146 children with simple UTI, MDR were also detected in 47 (77.05 %). There were 6 (9.84 %) positive for ESβL production. Our study found that complicated UTI was relatively common. Escherichia coli was the most prevalent isolate, followed by Enterococcus faecium and Enterococcus faecalis. These organisms were highly resistant to the most commonly used antibiotics. Relatively high prevalence of MDR and low ESβL-producing organisms were observed.
摘要：
尿路感染（UTI）是一种众所周知的细菌感染，对儿童造成严重的健康问题。进行了一项回顾性研究，以探讨UTI患儿的尿路病原体及其耐药性。收集尿培养和药敏试验数据。因此,包括840名儿童。总体培养阳性UTI为458（54.52%），大肠杆菌166（36.24%），其次是粪肠球菌59（12.88%），屎肠球菌70（15.28%）等。它们对最常用的抗生素具有高度抗性。在694名患有复杂UTI的儿童中，有8名儿童患有真菌感染。多重耐药（MDR）记录在315（80.98％）中。产超广谱β-内酰胺酶(ESβL)的总比例为25(6.43%)。146名患有简单UTI的儿童，47例(77.05%)也检出MDR。有6例(9.84%)ESβL产生阳性。我们的研究发现，复杂的UTI相对常见。大肠杆菌是最普遍的分离株,其次是屎肠球菌和粪肠球菌。这些生物对最常用的抗生素具有高度抗性。观察到相对较高的MDR患病率和低ESβL产生生物。
