PDF(Pubmed)
Abstract：
UNASSIGNED: Serum concentration of soluble growth stimulation expressed gene 2 (sST2) appears to have prognostic value in patients with aneurysmal subarachnoid hemorrhage (aSAH) by now. This study aimed to investigate the relationship between cerebrospinal fluid (CSF) sST2 concentration and outcome in patients with aSAH.
UNASSIGNED: A total of 65 aSAH patients who met the inclusion criteria in the Neurosurgery Department of Jining No.1 People\'s Hospital from March 2021 to August 2022 were selected as the research objects. 35 patients with the third month Modified-Rankin-Scale (mRS) score of 0-2 were divided into good prognosis group, and 30 patients with the third month mRS score of 3-5 were divided into poor prognosis group. CSF was collected by lumbar puncture for the first 5 days after aneurysm surgery. CSF sST2 concentration was determined using an enzyme-linked immunosorbent assay.
UNASSIGNED: In all patients, CSF sST2 concentrations initially increased, peaked on day 2, and then decreased. Compared with the good prognosis group, the sST2 concentration was significantly increased in the poor prognosis group at 1, 2, 3, 4 and 5 days after aSAH surgery. CSF sST2 concentration exhibited good diagnostic performance for predicting outcome (area under the receiver operating characteristic curve = 0.988). Additionally, CSF sST2 concentration has good performance for predicting cerebral edema, but only in the poor prognosis group (area under the curve = 0.93).
UNASSIGNED: Elevated CSF sST2 concentration is associated with poor outcome in aSAH patients. CSF sST2 may have a role as a predictive biomarker in these patients.
UNASSIGNED: A total of 65 aSAH patients who met the inclusion criteria in the Neurosurgery Department of Jining No.1 People\'s Hospital from March 2021 to August 2022 were selected as the research objects. 35 patients with the third month Modified-Rankin-Scale (mRS) score of 0-2 were divided into good prognosis group, and 30 patients with the third month mRS score of 3-5 were divided into poor prognosis group. CSF was collected by lumbar puncture for the first 5 days after aneurysm surgery. CSF sST2 concentration was determined using an enzyme-linked immunosorbent assay.
UNASSIGNED: In all patients, CSF sST2 concentrations initially increased, peaked on day 2, and then decreased. Compared with the good prognosis group, the sST2 concentration was significantly increased in the poor prognosis group at 1, 2, 3, 4 and 5 days after aSAH surgery. CSF sST2 concentration exhibited good diagnostic performance for predicting outcome (area under the receiver operating characteristic curve = 0.988). Additionally, CSF sST2 concentration has good performance for predicting cerebral edema, but only in the poor prognosis group (area under the curve = 0.93).
UNASSIGNED: Elevated CSF sST2 concentration is associated with poor outcome in aSAH patients. CSF sST2 may have a role as a predictive biomarker in these patients.
摘要：
■到目前为止，可溶性生长刺激表达基因2（sST2）的血清浓度似乎对动脉瘤性蛛网膜下腔出血（aSAH）患者具有预后价值。本研究旨在探讨aSAH患者脑脊液sST2浓度与预后的关系。
■选取2021年3月至2022年8月济宁市第一人民医院神经外科符合纳入标准的65例aSAH患者作为研究对象。将3个月改良Rankin量表(mRS)评分为0-2分的35例患者分为预后良好组,将30例3个月mRS评分为3～5分的患者分为预后不良组。在动脉瘤手术后的前5天通过腰椎穿刺收集CSF。使用酶联免疫吸附测定确定CSFsST2浓度。
■在所有患者中，CSFsST2浓度最初增加，在第2天达到峰值，然后下降。与预后良好组相比，预后不良组的sST2浓度在aSAH术后1,2,3,4和5天显著升高.CSFsST2浓度在预测结果方面表现出良好的诊断性能（受试者工作特征曲线下面积=0.988）。此外,CSFsST2浓度对预测脑水肿具有良好的性能，但仅限于预后不良组（曲线下面积=0.93）。
■CSFsST2浓度升高与aSAH患者的不良预后相关。CSFsST2在这些患者中可能具有作为预测性生物标志物的作用。
■选取2021年3月至2022年8月济宁市第一人民医院神经外科符合纳入标准的65例aSAH患者作为研究对象。将3个月改良Rankin量表(mRS)评分为0-2分的35例患者分为预后良好组,将30例3个月mRS评分为3～5分的患者分为预后不良组。在动脉瘤手术后的前5天通过腰椎穿刺收集CSF。使用酶联免疫吸附测定确定CSFsST2浓度。
■在所有患者中，CSFsST2浓度最初增加，在第2天达到峰值，然后下降。与预后良好组相比，预后不良组的sST2浓度在aSAH术后1,2,3,4和5天显著升高.CSFsST2浓度在预测结果方面表现出良好的诊断性能（受试者工作特征曲线下面积=0.988）。此外,CSFsST2浓度对预测脑水肿具有良好的性能，但仅限于预后不良组（曲线下面积=0.93）。
■CSFsST2浓度升高与aSAH患者的不良预后相关。CSFsST2在这些患者中可能具有作为预测性生物标志物的作用。
