PDF(Pubmed)
Abstract：
Bacteria-infected wounds healing has been greatly hindered by antibiotic resistance and persistent inflammation. It is crucial to develop multifunctional nanocomposites that possess effective antibacterial properties and can simultaneously accelerate the wound healing process to overcome the above challenges. Herein, we prepared a yolk-shell structured Ag nanowires (NWs)@amorphous hollow ZIF-67 by etching ZIF-67 onto the Ag NWs for infected wound healing for the first time. The etched hollow structure of amorphous ZIF-67 in the nanocomposite makes it a promising platform for loading healing-promoting drugs. We extensively studied the antibacterial and healing-promoting properties of the curcumin (CCM)-loaded nanocomposite (Ag NWs@C-HZ67). Ag NWs, being noble metal materials with plasmonic effects, can absorb a broad range of natural light and convert it to thermal energy. This photothermal conversion further improves the release of antibacterial components and wound healing drugs when exposed to light. During the healing process of an infected wound, Ag and Co ions were released from Ag NWs@C-HZ67 upon direct contact with the wound exudate and under the influence of light irradiation. Simultaneously, the loaded CCM leaked out to repair the infected wound. The minimum inhibitory concentrations of the Ag NWs@C-HZ67 groups against Escherichia coli and Staphylococcus aureus bacteria decreased to 3 and 3 μg ml-1 when exposed to white light. Furthermore, an in vivo assessment of infected wound healing demonstrated that combining Ag NWs@C-HZ67 with light significantly accelerated the wound healing process, achieving 70% healing by the 6th day and almost complete healing by the 8th day. This advanced nanocomposite, consisting of components that possess antibacterial and growth-promoting properties, offers a safe, effective and clinically-translatable solution for accelerating the healing process of infected wounds.
摘要：
细菌感染的伤口愈合受到抗生素耐药性和持续炎症的极大阻碍。开发具有有效抗菌性能并可同时加速伤口愈合过程以克服上述挑战的多功能纳米复合材料至关重要。在这里，我们首次通过在AgNWs上蚀刻ZIF-67，制备了卵黄壳结构的Ag纳米线（NWs）@无定形中空ZIF-67，用于感染的伤口愈合。纳米复合材料中无定形ZIF-67的蚀刻中空结构使其成为装载促进愈合药物的有希望的平台。我们广泛研究了姜黄素（CCM）负载的纳米复合材料（AgNWs@C-HZ67）的抗菌和促进愈合的特性。AgNWs,是具有等离子体激元效应的贵金属材料，可以吸收广泛的自然光并将其转化为热能。这种光热转化进一步改善了暴露于光时抗菌成分和伤口愈合药物的释放。在感染伤口的愈合过程中，与伤口渗出物直接接触并在光照射的影响下，AgNWs@C-HZ67释放出Ag和Co离子。同时,装载的CCM泄漏出来修复感染的伤口。暴露于白光时，AgNWs@C-HZ67组对大肠杆菌和金黄色葡萄球菌的最低抑菌浓度分别降至3和3μgml-1。此外，感染伤口愈合的体内评估表明，结合AgNWs@C-HZ67与光显著加速伤口愈合过程，到第6天达到70％的愈合，到第8天几乎完全愈合。这种先进的纳米复合材料，由具有抗菌和促进生长特性的成分组成，提供了一个保险箱，有效和临床翻译的解决方案，用于加速感染伤口的愈合过程。
