PDF(Pubmed)
Abstract：
UNASSIGNED: Ochrobactrum anthropi (O. anthropi), a rare opportunistic pathogen, caused sepsis in a malnourished 15-month-old African child. Early detection and appropriate antibiotics led to full recovery, highlighting the importance of robust surveillance for emerging pathogens in vulnerable populations.
UNASSIGNED: While rarely causing infections, O. anthropi, a non-fermenting, obligately aerobic, flagellated gram-negative bacillus, demonstrates oxidase positivity and indole negativity. Traditionally, Ochrobactrum spp is considered a low threat due to its environmental abundance and mild virulence. It is, however, a multidrug-resistant bacteria known for causing opportunistic infections in humans. O. anthropi is typically associated with catheter-related bloodstream infections. The first documented case was in 1998; most cases have been reported in developed countries. We present a case of O. anthropi sepsis in a malnourished child in sub-Saharan Africa. We report a case involving a 15-month-old African female who presented with symptoms and signs of protein-energy malnutrition and sepsis. The blood culture revealed O.anthropi. We treated the child with the empirical first-line antibiotics per the national guidelines, intravenous ampicillin and gentamicin for a week, and the child fully recovered. This report describes a rare case of O. anthropi sepsis with malnutrition in an African female child. O. anthropi is an emerging pathogen causing opportunistic infections in both immunocompetent and immunocompromised patients. We report that early bacterial detection, appropriate antibiotic susceptibility and antimicrobial management based on local antibiogram data may be essential for excellent patient outcomes. Additionally, we recommend more robust surveillance to detect such rare emerging pathogens.
UNASSIGNED: While rarely causing infections, O. anthropi, a non-fermenting, obligately aerobic, flagellated gram-negative bacillus, demonstrates oxidase positivity and indole negativity. Traditionally, Ochrobactrum spp is considered a low threat due to its environmental abundance and mild virulence. It is, however, a multidrug-resistant bacteria known for causing opportunistic infections in humans. O. anthropi is typically associated with catheter-related bloodstream infections. The first documented case was in 1998; most cases have been reported in developed countries. We present a case of O. anthropi sepsis in a malnourished child in sub-Saharan Africa. We report a case involving a 15-month-old African female who presented with symptoms and signs of protein-energy malnutrition and sepsis. The blood culture revealed O.anthropi. We treated the child with the empirical first-line antibiotics per the national guidelines, intravenous ampicillin and gentamicin for a week, and the child fully recovered. This report describes a rare case of O. anthropi sepsis with malnutrition in an African female child. O. anthropi is an emerging pathogen causing opportunistic infections in both immunocompetent and immunocompromised patients. We report that early bacterial detection, appropriate antibiotic susceptibility and antimicrobial management based on local antibiogram data may be essential for excellent patient outcomes. Additionally, we recommend more robust surveillance to detect such rare emerging pathogens.
摘要：
■人类嗜色杆菌（O.anthropi),一种罕见的机会病原体，导致一名15个月大的非洲营养不良儿童败血症。早期发现和适当的抗生素导致完全康复，强调对脆弱人群中新兴病原体进行强有力监测的重要性。
■虽然很少引起感染，O.anthropi,非发酵，强制有氧，鞭毛革兰阴性杆菌,显示氧化酶阳性和吲哚阴性。传统上,由于其环境丰度和温和的毒力，苍白杆菌属被认为是低威胁。是的,然而,一种多药耐药细菌，已知会引起人类机会性感染。O.anthropi通常与导管相关的血流感染有关。第一个记录在案的病例是在1998年；大多数病例是在发达国家报告的。我们介绍了撒哈拉以南非洲一名营养不良儿童的O.anthropi败血症病例。我们报告了一例涉及一名15个月大的非洲女性的病例，该女性出现了蛋白质能量营养不良和败血症的症状和体征。血培养显示O.Anthropi.我们根据国家指南对孩子进行了经验性的一线抗生素治疗，静脉注射氨苄青霉素和庆大霉素一周，孩子完全康复了.该报告描述了非洲女性儿童中营养不良的O.anthropi败血症的罕见病例。O.anthropi是一种新兴的病原体，可在免疫功能正常和免疫功能低下的患者中引起机会性感染。我们报告说早期细菌检测，基于局部抗菌药谱数据的适当抗生素敏感性和抗菌药物管理可能是患者预后良好的关键.此外,我们建议进行更强有力的监测,以检测这种罕见的新出现的病原体.
■虽然很少引起感染，O.anthropi,非发酵，强制有氧，鞭毛革兰阴性杆菌,显示氧化酶阳性和吲哚阴性。传统上,由于其环境丰度和温和的毒力，苍白杆菌属被认为是低威胁。是的,然而,一种多药耐药细菌，已知会引起人类机会性感染。O.anthropi通常与导管相关的血流感染有关。第一个记录在案的病例是在1998年；大多数病例是在发达国家报告的。我们介绍了撒哈拉以南非洲一名营养不良儿童的O.anthropi败血症病例。我们报告了一例涉及一名15个月大的非洲女性的病例，该女性出现了蛋白质能量营养不良和败血症的症状和体征。血培养显示O.Anthropi.我们根据国家指南对孩子进行了经验性的一线抗生素治疗，静脉注射氨苄青霉素和庆大霉素一周，孩子完全康复了.该报告描述了非洲女性儿童中营养不良的O.anthropi败血症的罕见病例。O.anthropi是一种新兴的病原体，可在免疫功能正常和免疫功能低下的患者中引起机会性感染。我们报告说早期细菌检测，基于局部抗菌药谱数据的适当抗生素敏感性和抗菌药物管理可能是患者预后良好的关键.此外,我们建议进行更强有力的监测,以检测这种罕见的新出现的病原体.
