PDF(Pubmed)
Abstract：
Ventricular meningiomas are neoplastic cells originating from the ependymal lining of the central canal of the spinal cord and the ventricles of the brain. These tumorigenic cells predominantly manifest in the fourth ventricle, followed by the spinal cord. Most intraparenchymal ventricular meningiomas are located within the brain tissue, exhibiting a higher degree of malignancy compared to their intracerebroventricular counterparts. While intracranial dissemination and metastasis to the spinal cord can occur, extra-neurologic metastasis is an exceedingly rare phenomenon that lacks a clear elucidation regarding its underlying mechanism. The authors presented a case of supratentorial brain parenchymal type ventricular meningioma surgical treatment in a young female patient, occurring two years after the development of multiple metastases in both lungs, pleura, and mediastinum. This may be attributed to the high malignancy degree and strong invasiveness of this lesion, as well as its proximity to the dura mater and venous sinus. The craniotomy provided an opportunity for tumor cells to invade the adjacent venous sinus, leading to dissemination through the blood system. Additionally, postoperative radiation and chemotherapy were administered to inhibit tumor angiogenesis; however, these treatments also increased the likelihood of tumor cell invasion into neighboring brain tissues and distant metastasis.
摘要：
脑室脑膜瘤是起源于脊髓中央管和脑室的室管膜衬里的肿瘤细胞。这些致瘤细胞主要表现在第四脑室，其次是脊髓。大多数脑实质内脑膜瘤位于脑组织内，与脑室内对应物相比，表现出更高的恶性程度。虽然可以发生颅内播散和脊髓转移，神经外转移是一种极为罕见的现象，缺乏对其潜在机制的明确阐明。作者介绍了一例年轻女性患者的幕上脑实质型脑室脑膜瘤手术治疗，发生在双肺多发转移发展两年后，胸膜,和纵隔。这可能归因于该病变的恶性程度高，侵袭性强，以及它靠近硬脑膜和静脉窦。开颅手术为肿瘤细胞侵入邻近的静脉窦提供了机会，导致通过血液系统传播。此外,术后给予放疗和化疗以抑制肿瘤血管生成；然而，这些治疗也增加了肿瘤细胞侵入邻近脑组织和远处转移的可能性。
