PDF(Pubmed)
Abstract：
Zebrafish being the best animal model to study, every attempt has been made to decipher the toxic mechanism of every fungicide of usage and interest. It is important to understand the multiple targets of a toxicant to estimate the toxic potential in its totality. A total of 22 fungicides of different classes like amisulbrom, azoxystrobin, carbendazim, carboxin, chlorothalonil, difenoconazole, etridiazole, flusilazole, fluxapyroxad, hexaconazole, kresoxim methyl, mancozeb, myclobutanil, prochloraz, propiconazole, propineb, pyraclostrobin, tebuconazole, thiophanate-methyl, thiram, trifloxystrobin and ziram were reviewed and analyzed for their multiple explored targets in zebrafish. Toxic end points in zebrafish are highly informative when it comes to network analysis. They provide a window into the molecular and cellular pathways that are affected by a certain toxin. This can then be used to gain insights into the underlying mechanisms of toxicity and to draw conclusions on the potential of a particular compound to induce toxicity. This knowledge can then be used to inform decisions about drug development, environmental regulation, and other areas of research. In addition, the use of zebrafish toxic end points can also be used to better understand the effects of environmental pollutants on ecosystems. By understanding the pathways affected by a given toxin, researchers can determine how pollutants may interact with the environment and how this could lead to health or environmental impacts.
摘要：
斑马鱼是最好的动物模型，已经尝试破译每种使用和感兴趣的杀菌剂的毒性机制。重要的是要了解毒物的多个目标，以估计其整体的毒性潜力。共有22种不同类别的杀菌剂，如抗菌药，唑霉素,多菌灵,羧基,百菌清,苯醚甲环唑,Etridiazole,氟西拉唑,fluxapyroxad,己唑醇,克雷辛磷甲基,代森锰锌,myclobutanil,丙草胺,丙环唑,propineb,吡唑酮酯,戊唑醇,甲基托布津，硫兰,对triploxystrobin和ziram在斑马鱼中的多个探索靶标进行了回顾和分析。当涉及到网络分析时，斑马鱼的毒性终点信息非常丰富。它们提供了进入受某种毒素影响的分子和细胞途径的窗口。然后，这可以用来深入了解潜在的毒性机制，并得出结论特定化合物诱导毒性的潜力。然后，这些知识可以用于指导有关药物开发的决策，环境法规,和其他研究领域。此外,使用斑马鱼的毒性终点也可用于更好地了解环境污染物对生态系统的影响。通过了解受给定毒素影响的途径，研究人员可以确定污染物如何与环境相互作用，以及如何导致健康或环境影响。
