PDF(Pubmed)
Abstract：
Recent studies have shifted the spotlight from adult disease to gametogenesis and embryo developmental events, and these are greatly affected by various environmental chemicals, such as drugs, metabolites, pollutants, and others. Growing research has highlighted the critical importance of identifying and understanding the roles of chemicals in reproductive biology. However, the functions and mechanisms of chemicals in reproductive processes remain incomplete. We developed a comprehensive database called the Reproductive Chemical Database (RCDB) ( https://yu.life.sjtu.edu.cn/ChenLab/RCDB ) to facilitate research on chemicals in reproductive biology. This resource is founded on rigorous manual literature extraction and precise protein target prediction methodologies. This database focuses on the delineation of chemicals associated with phenotypes, diseases, or endpoints intricately associated with four important reproductive processes: female and male gamete generation, fertilization, and embryo development in human and mouse. The RCDB encompasses 93 sub-GO processes, and it revealed 1447 intricate chemical-biological process interactions. To date, the RCDB has meticulously cataloged and annotated 830 distinct chemicals, while also predicting 614 target proteins from a selection of 3800 potential candidates. Additionally, the RCDB offers an online predictive tool that empowers researchers to ascertain whether specific chemicals play discernible functional roles in these reproductive processes. The RCDB is an exhaustive, cross-platform, manually curated database, which provides a user-friendly interface to search, browse, and use reproductive processes modulators and their comprehensive related information. The RCDB will help researchers to understand the whole reproductive process and related diseases and it has the potential to promote reproduction research in the pharmacological and pathophysiological areas.
摘要：
最近的研究已经将焦点从成人疾病转移到配子发生和胚胎发育事件,这些受到各种环境化学物质的极大影响，比如毒品，代谢物，污染物，和其他人。越来越多的研究强调了识别和理解化学物质在生殖生物学中的作用的至关重要性。然而,化学物质在生殖过程中的功能和机制仍然不完整。我们开发了一个名为生殖化学数据库（RCDB）的综合数据库（https://yu。生活。sjtu.edu.cn/ChenLab/RCDB）促进生殖生物学中化学物质的研究。该资源基于严格的手工文献提取和精确的蛋白质靶标预测方法。该数据库侧重于与表型相关的化学物质的描述，疾病,或终点与四个重要的生殖过程密切相关：雌性和雄性配子的产生，受精,人类和小鼠的胚胎发育。RCDB包括93个子GO工艺，它揭示了1447年复杂的化学-生物过程相互作用。迄今为止,RCDB精心编目和注释了830种不同的化学品，同时还从3800个潜在候选物中预测614个靶蛋白。此外,RCDB提供了一种在线预测工具，使研究人员能够确定特定化学物质是否在这些生殖过程中发挥明显的功能作用。RCDB是一个详尽的，跨平台,手动策划的数据库，它提供了一个用户友好的搜索界面，浏览,并使用生殖过程调节剂及其全面的相关信息。RCDB将帮助研究人员了解整个生殖过程和相关疾病，并有可能促进药理和病理生理领域的生殖研究。
