PDF(Pubmed)
Abstract：
BACKGROUND: The pathogenesis of migraine remains unclear; however, a large body of evidence supports the hypothesis that immunological mechanisms play a key role. Therefore, we aimed to review current studies on altered immunity in individuals with migraine during and outside attacks.
METHODS: We searched the PubMed database to investigate immunological changes in patients with migraine. We then added other relevant articles on altered immunity in migraine to our search.
RESULTS: Database screening identified 1,102 articles, of which 41 were selected. We added another 104 relevant articles. We found studies reporting elevated interictal levels of some proinflammatory cytokines, including IL-6 and TNF-α. Anti-inflammatory cytokines showed various findings, such as increased TGF-β and decreased IL-10. Other changes in humoral immunity included increased levels of chemokines, adhesion molecules, and matrix metalloproteinases; activation of the complement system; and increased IgM and IgA. Changes in cellular immunity included an increase in T helper cells, decreased cytotoxic T cells, decreased regulatory T cells, and an increase in a subset of natural killer cells. A significant comorbidity of autoimmune and allergic diseases with migraine was observed.
CONCLUSIONS: Our review summarizes the findings regarding altered humoral and cellular immunological findings in human migraine. We highlight the possible involvement of immunological mechanisms in the pathogenesis of migraine. However, further studies are needed to expand our knowledge of the exact role of immunological mechanisms in migraine pathogenesis.
METHODS: We searched the PubMed database to investigate immunological changes in patients with migraine. We then added other relevant articles on altered immunity in migraine to our search.
RESULTS: Database screening identified 1,102 articles, of which 41 were selected. We added another 104 relevant articles. We found studies reporting elevated interictal levels of some proinflammatory cytokines, including IL-6 and TNF-α. Anti-inflammatory cytokines showed various findings, such as increased TGF-β and decreased IL-10. Other changes in humoral immunity included increased levels of chemokines, adhesion molecules, and matrix metalloproteinases; activation of the complement system; and increased IgM and IgA. Changes in cellular immunity included an increase in T helper cells, decreased cytotoxic T cells, decreased regulatory T cells, and an increase in a subset of natural killer cells. A significant comorbidity of autoimmune and allergic diseases with migraine was observed.
CONCLUSIONS: Our review summarizes the findings regarding altered humoral and cellular immunological findings in human migraine. We highlight the possible involvement of immunological mechanisms in the pathogenesis of migraine. However, further studies are needed to expand our knowledge of the exact role of immunological mechanisms in migraine pathogenesis.
摘要：
背景：偏头痛的发病机制尚不清楚；然而，大量证据支持免疫机制起关键作用的假说。因此,我们旨在回顾目前有关偏头痛患者在发作期间和发作外免疫力改变的研究.
方法：我们搜索了PubMed数据库以调查偏头痛患者的免疫学变化。然后，我们在搜索中添加了有关偏头痛免疫力改变的其他相关文章。
结果：数据库筛选确定了1,102篇文章，其中41人被选中。我们又增加了104篇相关文章。我们发现研究报告了一些促炎细胞因子的间期水平升高，包括IL-6和TNF-α。抗炎细胞因子显示了各种发现，如TGF-β增加和IL-10减少。体液免疫的其他变化包括趋化因子水平升高，粘附分子,和基质金属蛋白酶；补体系统的激活；IgM和IgA增加。细胞免疫的变化包括T辅助细胞的增加，细胞毒性T细胞减少，减少调节性T细胞，以及自然杀伤细胞亚群的增加。观察到自身免疫性和过敏性疾病与偏头痛的显着合并症。
结论：我们的综述总结了关于人类偏头痛体液和细胞免疫学发现改变的发现。我们强调了免疫机制可能参与偏头痛的发病机理。然而,需要进一步的研究来扩大我们对免疫机制在偏头痛发病机制中的确切作用的认识.
方法：我们搜索了PubMed数据库以调查偏头痛患者的免疫学变化。然后，我们在搜索中添加了有关偏头痛免疫力改变的其他相关文章。
结果：数据库筛选确定了1,102篇文章，其中41人被选中。我们又增加了104篇相关文章。我们发现研究报告了一些促炎细胞因子的间期水平升高，包括IL-6和TNF-α。抗炎细胞因子显示了各种发现，如TGF-β增加和IL-10减少。体液免疫的其他变化包括趋化因子水平升高，粘附分子,和基质金属蛋白酶；补体系统的激活；IgM和IgA增加。细胞免疫的变化包括T辅助细胞的增加，细胞毒性T细胞减少，减少调节性T细胞，以及自然杀伤细胞亚群的增加。观察到自身免疫性和过敏性疾病与偏头痛的显着合并症。
结论：我们的综述总结了关于人类偏头痛体液和细胞免疫学发现改变的发现。我们强调了免疫机制可能参与偏头痛的发病机理。然而,需要进一步的研究来扩大我们对免疫机制在偏头痛发病机制中的确切作用的认识.
