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Abstract：
BACKGROUND: Life\'s Essential 8 (LE8), the recently updated construct for quantifying cardiovascular health, is related to the risks of cardiovascular events. The present study aimed to evaluate associations of LE8 score with the multi-territorial extent of atherosclerosis in a community-dwelling population.
METHODS: Data were derived from the baseline cross-sectional survey of the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study in Lishui City. The LE8 included overall, medical and behavior LE8 scores, and were categorized as low (< 60), moderate (60-<80), and high (≥ 80) groups. Vascular magnetic resonance imaging was used to evaluate intracranial and extracranial arteries; thoracoabdominal computed tomography angiography to evaluate coronary, subclavian, aorta, renal, ilio-femoral arteries; and ankle-brachial index to evaluate peripheral arteries. The presence of atherosclerotic plaque or stenosis in any territory was defined as plaque or vascular stenosis with 1 territory affected or more in these arteries. The extent of atherosclerotic plaques or stenosis was assessed according to the number of these 8 vascular sites affected, and graded as four grades (none, single territory, 2-3 territories, 4-8 territories).
RESULTS: Of 3065 included participants, the average age was 61.2 ± 6.7 years, and 53.5% were women (n = 1639). The moderate and high overall LE8 groups were associated with lower extent of multi-territorial plaques [common odds ratio (cOR) 0.44, 95% confidence interval (CI), 0.35-0.55; cOR 0.16, 95%CI, 0.12-0.21; respectively] and stenosis (cOR 0.51, 95%CI, 0.42-0.62; cOR 0.16, 95%CI, 0.12-0.21; respectively) after adjustment for potential covariates. Similar results were observed for medical LE8 score with the extent of multi-territorial plaques and stenosis (P < 0.05). We also found the association between behavior LE8 score and the extent of multi-territorial stenosis (P < 0.05).
CONCLUSIONS: The higher LE8 scores, indicating healthier lifestyle, were associated with lower presence and extent of atherosclerotic plaque and stenosis in southern Chinese adults. Prospective studies are needed to further validate these findings.
METHODS: Data were derived from the baseline cross-sectional survey of the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study in Lishui City. The LE8 included overall, medical and behavior LE8 scores, and were categorized as low (< 60), moderate (60-<80), and high (≥ 80) groups. Vascular magnetic resonance imaging was used to evaluate intracranial and extracranial arteries; thoracoabdominal computed tomography angiography to evaluate coronary, subclavian, aorta, renal, ilio-femoral arteries; and ankle-brachial index to evaluate peripheral arteries. The presence of atherosclerotic plaque or stenosis in any territory was defined as plaque or vascular stenosis with 1 territory affected or more in these arteries. The extent of atherosclerotic plaques or stenosis was assessed according to the number of these 8 vascular sites affected, and graded as four grades (none, single territory, 2-3 territories, 4-8 territories).
RESULTS: Of 3065 included participants, the average age was 61.2 ± 6.7 years, and 53.5% were women (n = 1639). The moderate and high overall LE8 groups were associated with lower extent of multi-territorial plaques [common odds ratio (cOR) 0.44, 95% confidence interval (CI), 0.35-0.55; cOR 0.16, 95%CI, 0.12-0.21; respectively] and stenosis (cOR 0.51, 95%CI, 0.42-0.62; cOR 0.16, 95%CI, 0.12-0.21; respectively) after adjustment for potential covariates. Similar results were observed for medical LE8 score with the extent of multi-territorial plaques and stenosis (P < 0.05). We also found the association between behavior LE8 score and the extent of multi-territorial stenosis (P < 0.05).
CONCLUSIONS: The higher LE8 scores, indicating healthier lifestyle, were associated with lower presence and extent of atherosclerotic plaque and stenosis in southern Chinese adults. Prospective studies are needed to further validate these findings.
摘要：
背景：生活的基本8（LE8），最近更新的量化心血管健康的结构，与心血管事件的风险有关。本研究旨在评估社区居民中LE8评分与动脉粥样硬化多地域范围的关联。
方法：数据来自丽水市多血管评估认知障碍和风险事件（PRECISE）研究的基线横断面调查。LE8包括整体，医学和行为LE8评分，并被归类为低(<60)，中等（60-<80），和高（≥80）组。血管磁共振成像用于评估颅内和颅外动脉；胸腹CT血管造影用于评估冠状动脉，锁骨下,主动脉,肾,髂股动脉和踝肱指数评估外周动脉。在任何区域中动脉粥样硬化斑块或狭窄的存在被定义为在这些动脉中具有1个或更多区域受影响的斑块或血管狭窄。根据这8个受影响的血管部位的数量评估动脉粥样硬化斑块或狭窄的程度。并分级为四级(没有，单一领土,2-3个领土，4-8个地区）。
结果：在3065名参与者中，平均年龄为61.2±6.7岁，53.5%为女性(n=1639)。中、高总体LE8组与较低程度的多区域斑块相关[共同比值比(cOR)0.44,95%置信区间(CI),0.35-0.55；cOR0.16，95CI，0.12-0.21；分别]和狭窄（cOR0.51，95CI，0.42-0.62；cOR0.16，95CI，0.12-0.21；分别）。医学LE8评分与多区域斑块和狭窄程度相似（P<0.05）。我们还发现行为LE8评分与多区域狭窄程度之间存在关联（P<0.05）。
结论：LE8分数越高，表明更健康的生活方式，与中国南方成年人动脉粥样硬化斑块和狭窄的存在和程度较低有关。需要前瞻性研究来进一步验证这些发现。
方法：数据来自丽水市多血管评估认知障碍和风险事件（PRECISE）研究的基线横断面调查。LE8包括整体，医学和行为LE8评分，并被归类为低(<60)，中等（60-<80），和高（≥80）组。血管磁共振成像用于评估颅内和颅外动脉；胸腹CT血管造影用于评估冠状动脉，锁骨下,主动脉,肾,髂股动脉和踝肱指数评估外周动脉。在任何区域中动脉粥样硬化斑块或狭窄的存在被定义为在这些动脉中具有1个或更多区域受影响的斑块或血管狭窄。根据这8个受影响的血管部位的数量评估动脉粥样硬化斑块或狭窄的程度。并分级为四级(没有，单一领土,2-3个领土，4-8个地区）。
结果：在3065名参与者中，平均年龄为61.2±6.7岁，53.5%为女性(n=1639)。中、高总体LE8组与较低程度的多区域斑块相关[共同比值比(cOR)0.44,95%置信区间(CI),0.35-0.55；cOR0.16，95CI，0.12-0.21；分别]和狭窄（cOR0.51，95CI，0.42-0.62；cOR0.16，95CI，0.12-0.21；分别）。医学LE8评分与多区域斑块和狭窄程度相似（P<0.05）。我们还发现行为LE8评分与多区域狭窄程度之间存在关联（P<0.05）。
结论：LE8分数越高，表明更健康的生活方式，与中国南方成年人动脉粥样硬化斑块和狭窄的存在和程度较低有关。需要前瞻性研究来进一步验证这些发现。
